A
Ahmed A. Al-Karmalawy
Researcher at Al-Azhar University
Publications - 107
Citations - 2315
Ahmed A. Al-Karmalawy is an academic researcher from Al-Azhar University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 17, co-authored 44 publications receiving 564 citations.
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Journal ArticleDOI
Design, synthesis, molecular docking, and anticancer activity of benzoxazole derivatives as VEGFR-2 inhibitors.
Abdel-Ghany A. El-Helby,Helmy Sakr,Ibrahim H. Eissa,Hamada S. Abulkhair,Ahmed A. Al-Karmalawy,Khaled El-Adl,Khaled El-Adl +6 more
TL;DR: Novel series of benzoxazoles 4a‐f‐16 was designed, synthesized, and evaluated for anticancer activity against HepG2, HCT‐116, and MCF‐7 cells, finding compound 5e was found to be the most potent against hepatitis B cells with IC50 values of 5.93 ± 0.5 µM, respectively.
Journal ArticleDOI
Molecular Docking and Dynamics Simulation Revealed the Potential Inhibitory Activity of ACEIs Against SARS-CoV-2 Targeting the h ACE2 Receptor.
Ahmed A. Al-Karmalawy,Mohammed A. Dahab,Ahmed M. Metwaly,Sameh S. Elhady,Eslam B. Elkaeed,Ibrahim H. Eissa,Khaled M. Darwish +6 more
TL;DR: In this paper, the authors considered drug repurposing as an attractive approach that can facilitate the drug discovery process by reusing existing pharmaceuticals to treat illnesses other than their primary indications.
Journal ArticleDOI
Molecular docking, molecular dynamics, and in vitro studies reveal the potential of angiotensin II receptor blockers to inhibit the COVID-19 main protease.
TL;DR: A virtual screening for almost all members of ARBs against COVID-19 main protease to give a clear spot on the structure-activity relationship (SAR) required for the future design of new drugs targeting the newly emerged SARS-CoV-2 protease by medicinal chemists.
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Anti-SARS-CoV-2 activities of tanshinone IIA, carnosic acid, rosmarinic acid, salvianolic acid, baicalein, and glycyrrhetinic acid between computational and in vitro insights
Dalia Elebeedy,Walid F. Elkhatib,Ahmed Kandeil,Aml Ghanem,Omnia Kutkat,Radwan Alnajjar,Radwan Alnajjar,Marwa A. Saleh,Ahmed I. Abd El Maksoud,Ingy Badawy,Ahmed A. Al-Karmalawy +10 more
TL;DR: Six compounds were screened for their anti-SARS-CoV-2 activities against both the spike (S) and main protease (Mpro) receptors using molecular docking studies and showed very promising virucidal activity with a most prominent inhibitory effect on viral adsorption rather than its replication.
Journal ArticleDOI
Benzoxazole/benzothiazole-derived VEGFR-2 inhibitors: Design, synthesis, molecular docking, and anticancer evaluations.
Abdel-Ghany A. El-Helby,Helmy Sakr,Ibrahim H. Eissa,Ahmed A. Al-Karmalawy,Khaled El-Adl,Khaled El-Adl +5 more
TL;DR: A novel series of benzoxazole/benzothiazole derivatives 4a–c–11a–e was designed, synthesized, and evaluated for anticancer activity against HepG2, HCT‐116, and MCF‐7 cells, with compound 4c found to be the most potent derivative.