A
Ai Li
Researcher at Amgen
Publications - 22
Citations - 3380
Ai Li is an academic researcher from Amgen. The author has contributed to research in topics: Talimogene laherparepvec & Oncolytic virus. The author has an hindex of 15, co-authored 22 publications receiving 2784 citations. Previous affiliations of Ai Li include University of California, Los Angeles & Novartis.
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Journal ArticleDOI
Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma
Robert H.I. Andtbacka,Howard L. Kaufman,Frances A. Collichio,Thomas Amatruda,Neil Senzer,Jason Chesney,Keith A. Delman,Lynn E. Spitler,Igor Puzanov,Sanjiv S. Agarwala,Mohammed M. Milhem,Lee D. Cranmer,Brendan D. Curti,Karl D. Lewis,Merrick I. Ross,Troy H. Guthrie,Gerald P. Linette,Gregory A. Daniels,Kevin J. Harrington,Mark R. Middleton,Wilson H. Miller,Jonathan S. Zager,Yining Ye,Bin Yao,Ai Li,Susan Doleman,Ari M. Vanderwalde,Jennifer Gansert,Robert Coffin +28 more
TL;DR: T-VEC is the first oncolytic immunotherapy to demonstrate therapeutic benefit against melanoma in a phase III clinical trial and represents a novel potential therapy for patients with metastatic melanoma.
Journal ArticleDOI
Talimogene Laherparepvec in Combination With Ipilimumab in Previously Untreated, Unresectable Stage IIIB-IV Melanoma
Igor Puzanov,Mohammed M. Milhem,David R. Minor,Omid Hamid,Ai Li,Lisa Chen,Michael Chastain,Kevin S. Gorski,Abraham Antonio Anderson,Jeffrey Chou,Howard L. Kaufman,Robert H.I. Andtbacka +11 more
TL;DR: T-V EC with ipilimumab had a tolerable safety profile, and the combination appeared to have greater efficacy than either T-VEC or ipilimimumab monotherapy.
Journal ArticleDOI
Weighted Gene Coexpression Network Analysis: State of the Art
TL;DR: Key concepts of WGCNA are reviewed and some of its applications in gene expression analysis of oncology, brain function, and protein interaction data are reviewed.
Journal ArticleDOI
Network neighborhood analysis with the multi-node topological overlap measure
Ai Li,Steve Horvath +1 more
TL;DR: The pairwise topological overlap measure is generalized to multiple network nodes and subsequently used in a recursive neighborhood construction method, and empirical evidence that the resulting neighborhoods are biologically meaningful is provided.
Journal ArticleDOI
Aromatase expression predicts survival in women with early-stage non small cell lung cancer.
Vei Mah,David Seligson,Ai Li,Diana C. Márquez,Ignacio I. Wistuba,Yahya Elshimali,Michael C. Fishbein,David Chia,Richard J. Pietras,Lee Goodglick +9 more
TL;DR: The findings implicate aromatase as an early-stage predictor of survival in some women with NSCLC and predict that women whose lung cancers have higher levels of aromat enzyme might be good candidates for targeted treatment with aromatases inhibitors.