Aiguo Li

TL;DR: Significant phenotypic and genotypic differences are demonstrated between primary human tumor-derived TSCs and their matched glioma cell lines, suggesting that TSC's may be a more reliable model than many commonly utilized cancer cell lines for understanding the biology of primary human tumors.

TL;DR: It is demonstrated that both bone morphogenetic protein (BMP)-mediated and ciliary neurotrophic factor (CNTF)-mediated Jak/STAT-dependent astroglial differentiation is impaired due to EZH2-dependent epigenetic silencing of BMP receptor 1B (BMPR1B) in a subset of glioblastoma TICs.

TL;DR: It is indicated that established cancer cell lines are generally a poor representation of primary tumor biology, presenting a host of genomic and gene expression changes not observed in primary tissues, although some discrete features of glioma biology were conserved in the established cell lines.

TL;DR: Application of the classification system to the external glioma data sets allowed us to identify previously unrecognized prognostic groups within previously published data and within The Cancer Genome Atlas glioblastoma samples and the different biological pathways associated with the different gliomas subtypes offering a potential clue to the pathogenesis and possibly therapeutic targets for tumors within each subtype.

TL;DR: A CTGF-rich microenvironment facilitates CT GF-ITGB1-TrkA complex activation in TIC/TSCs, thereby increasing the invasiveness of malignant gliomas.