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Aikaterini Alexaki
Researcher at Center for Biologics Evaluation and Research
Publications - 18
Citations - 854
Aikaterini Alexaki is an academic researcher from Center for Biologics Evaluation and Research. The author has contributed to research in topics: Codon usage bias & Gene. The author has an hindex of 8, co-authored 16 publications receiving 526 citations.
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Journal ArticleDOI
Recent advances in (therapeutic protein) drug development
H.A. Daniel Lagassé,Aikaterini Alexaki,Vijaya L. Simhadri,Nobuko H. Katagiri,Wojciech Jankowski,Zuben E. Sauna,Chava Kimchi-Sarfaty +6 more
TL;DR: This review highlights the emerging trends and approaches in protein drug development by using examples of therapeutic proteins approved by the U.S. Food and Drug Administration over the previous five years (2011–2016, namely January 1, 2011, through August 31, 2016).
Journal ArticleDOI
A new and updated resource for codon usage tables
John C. Athey,Aikaterini Alexaki,Ekaterina Osipova,Alexandre Rostovtsev,Luis V. Santana-Quintero,Upendra K. Katneni,Vahan Simonyan,Chava Kimchi-Sarfaty +7 more
TL;DR: A new database, the High-performance Integrated Virtual Environment-Codon Usage Tables (HIVE-CUTs), to present and analyse codon usage tables for every organism with publicly available sequencing data, which will facilitate effective development and review of recombinant drug products and will be instrumental in a wide area of biological research.
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Codon and Codon-Pair Usage Tables (CoCoPUTs): Facilitating Genetic Variation Analyses and Recombinant Gene Design.
Aikaterini Alexaki,Jacob Kames,David D. Holcomb,John C. Athey,Luis V. Santana-Quintero,Phuc Vihn Nguyen Lam,Nobuko Hamasaki-Katagiri,Ekaterina Osipova,Vahan Simonyan,Haim Bar,Anton A. Komar,Chava Kimchi-Sarfaty +11 more
TL;DR: A new database is constructed to include genomic codon-pair and dinucleotide statistics of all organisms with sequenced genome, available in the GenBank, and is believed to be an invaluable tool to many researchers in academia and pharmaceutical industry.
Journal ArticleDOI
Coagulopathy and Thrombosis as a Result of Severe COVID-19 Infection: A Microvascular Focus.
Upendra K. Katneni,Aikaterini Alexaki,Ryan C. Hunt,Tal Schiller,Michael DiCuccio,Paul W. Buehler,Juan C. Ibla,Chava Kimchi-Sarfaty +7 more
TL;DR: A thorough understanding of VWF-ADAMTS-13 interactions during early and advanced phases of COVID-19 could help better define the pathophysiology, guide thromboprophylaxis and treatment, and improve clinical prognosis.
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Sequence analysis of SARS-CoV-2 genome reveals features important for vaccine design
Jacob Kames,David D. Holcomb,Ofer Kimchi,Michael DiCuccio,Nobuko Hamasaki-Katagiri,Tony T. Wang,Anton A. Komar,Aikaterini Alexaki,Chava Kimchi-Sarfaty +8 more
TL;DR: This analysis identified the spike (S) and nucleocapsid (N) proteins as promising targets for deoptimization and suggests a roadmap for SARS-CoV-2 vaccine development, which can be generalizable to other viruses.