A
Aimée M. Dudley
Researcher at Pacific Northwest Diabetes Research Institute
Publications - 56
Citations - 2757
Aimée M. Dudley is an academic researcher from Pacific Northwest Diabetes Research Institute. The author has contributed to research in topics: Gene & Saccharomyces cerevisiae. The author has an hindex of 22, co-authored 50 publications receiving 2524 citations. Previous affiliations of Aimée M. Dudley include Harvard University & Academy of Sciences of the Czech Republic.
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A global view of pleiotropy and phenotypically derived gene function in yeast
TL;DR: The degree of pleiotropy in yeast is estimated by measuring the phenotypes of 4710 mutants under 21 environmental conditions, finding that it is significantly higher than predicted by chance.
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Measuring absolute expression with microarrays with a calibrated reference sample and an extended signal intensity range.
TL;DR: This study hybridizes each sample against labeled oligos complementary to every microarray feature, and demonstrates that results from this type of hybridization are accurate and retain absolute abundance information far better than conventional microarray ratios.
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The Spt components of SAGA facilitate TBP binding to a promoter at a post-activator-binding step in vivo
TL;DR: The results suggest a coactivator role for Spt3 and Spt20 in the recruitment of TBP, which is required for the binding of TATA-binding protein but not of the activator Gal4 and that this role is Gcn5 independent.
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Learning a prior on regulatory potential from eQTL data.
Su-In Lee,Aimée M. Dudley,David A. Drubin,Pamela A. Silver,Nevan J. Krogan,Dana Pe'er,Daphne Koller +6 more
TL;DR: A novel method, Lirnet, is presented that automatically learns a regulatory potential for each sequence polymorphism, estimating how likely it is to have a significant effect on gene expression, and produces significantly better regulatory programs than other recent approaches.
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Surface plasmon resonance biosensor for rapid label-free detection of microribonucleic acid at subfemtomole level.
TL;DR: A novel method for rapid and sensitive miRNA detection and quantitation using surface plasmon resonance (SPR) sensor technology and a DNA*RNA antibody-based assay and results which agree well with those provided by the quantitative polymerase chain reaction (qPCR).