Zinger Yang

TL;DR: The results indicate that Cas9 toxicity creates an obstacle to the high-throughput use of CRISPR/Cas9 for genome engineering and screening in hPSCs, and as h PSCs can acquire P53 mutations14, cell replacement therapies using CRISpr/cas9-enginereed hPSCS should proceed with caution, and such engineered hPSPs should be monitored for P53 function.

TL;DR: It is found that BECs lack and do not require LGR4/5-mediated WNT/β-catenin signaling during a DR, whereas YAP and mTORC1 signaling are required for this process.

TL;DR: It is proposed that TMEM41B is a novel ER‐localized regulator of autophagosome biogenesis and lipid mobilization and Immunostaining and interaction proteomics data suggest that TM EM41B localizes to the endoplasmic reticulum (ER).

TL;DR: The finding of a broad adipocyte repertoire derived from a distinct set of mesenchymal progenitors, and of the transcriptional regulators that can control their development, provides a framework for understanding human adipose tissue function and role in metabolic disease.

TL;DR: It is concluded that fetal and placental mRNA circulates in the blood of pregnant women and placedental genes are more easily detected in plasma.