Chaoyang Ye

TL;DR: The results indicate that Cas9 toxicity creates an obstacle to the high-throughput use of CRISPR/Cas9 for genome engineering and screening in hPSCs, and as h PSCs can acquire P53 mutations14, cell replacement therapies using CRISpr/cas9-enginereed hPSCS should proceed with caution, and such engineered hPSPs should be monitored for P53 function.

TL;DR: The genomes of two socially divergent ant species exhibiting differences in caste development are sequenced and used to compare gene expression and identify differences in epigenetic gene regulation that lead to the phenotypic differences.

TL;DR: RNF20 depletion augmented the transcriptional effects of epidermal growth factor, increased cell migration, and elicited transformation and tumorigenesis in tumors, and may be a putative tumor suppressor, acting through selective regulation of a distinct subset of genes.

TL;DR: It is shown that genetic ablation of AXL has no effect on ZikV entry or ZIKV-mediated cell death in human induced pluripotent stem cell (iPSC)-derived NPCs or cerebral organoids, calling into question the utility of A XL inhibitors for preventing birth defects after infection.

TL;DR: It is proposed that epigenetic mechanisms that modify chromatin structure may help orchestrate the generation and maintenance of polyphenic caste morphology and social behavior in ants.