A
Akane Itou
Researcher at University of Tokyo
Publications - 5
Citations - 760
Akane Itou is an academic researcher from University of Tokyo. The author has contributed to research in topics: Fiber cell & Cell. The author has an hindex of 3, co-authored 5 publications receiving 639 citations.
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Journal ArticleDOI
Metre-long cell-laden microfibres exhibit tissue morphologies and functions
Hiroaki Onoe,Teru Okitsu,Akane Itou,Midori Kato-Negishi,Riho Gojo,Daisuke Kiriya,Koji Sato,Shigenori Miura,Shintaroh Iwanaga,Kaori Kuribayashi-Shigetomi,Yukiko T. Matsunaga,Yuto Shimoyama,Shoji Takeuchi +12 more
TL;DR: Fibres encapsulating primary pancreatic islet cells and transplanted through a microcatheter into the subrenal capsular space of diabetic mice normalized blood glucose concentrations for about two weeks and may find use as templates for the reconstruction of fibre-shaped functional tissues that mimic muscle fibres, blood vessels or nerve networks in vivo.
Journal ArticleDOI
Differentiation Induction of Mouse Neural Stem Cells in Hydrogel Tubular Microenvironments with Controlled Tube Dimensions.
TL;DR: It is found that the tubular microenvironment with a core diameter of less than ≈100 μm contributes to forming highly viable and aligned neural tissue and can provide an effective method for constructing microfiber‐shaped neural tissues with geometrically controlled differentiation induction.
Journal ArticleDOI
Cell fibers promote proliferation of co-cultured cells on a dish.
TL;DR: It is suggested that the secretome of 3T3 fibers promoted survival and proliferation of C2C12 cells, suggesting that cell fiber technology is a useful tool for co-culturing cells and it will contribute to both basic cell biology and tissue engineering with its unique features.
Journal ArticleDOI
Cell-laden microfibers fabricated using μL cell-suspension.
TL;DR: Investigations on the morphology and function of the encapsulated cells show the viability of the cells is not significantly affected by the fabrication process, and indicate the potential of using the method to perform quantitative assays on fiber-shaped tissues, while reducing the overall material- and time- consumption.
Long-term implantation of primary islet cell-encapsulating hydrogel microfibers in diabetic mice
TL;DR: This result shows that the cell fiber approach can be applied to long-term implantation and can provide primary islet cells with sufficient microenvironment to promote cellular functions in vivo.