S
Shigenori Miura
Researcher at University of Tokyo
Publications - 19
Citations - 968
Shigenori Miura is an academic researcher from University of Tokyo. The author has contributed to research in topics: Extracellular matrix & Tissue engineering. The author has an hindex of 5, co-authored 17 publications receiving 791 citations.
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Journal ArticleDOI
Metre-long cell-laden microfibres exhibit tissue morphologies and functions
Hiroaki Onoe,Teru Okitsu,Akane Itou,Midori Kato-Negishi,Riho Gojo,Daisuke Kiriya,Koji Sato,Shigenori Miura,Shintaroh Iwanaga,Kaori Kuribayashi-Shigetomi,Yukiko T. Matsunaga,Yuto Shimoyama,Shoji Takeuchi +12 more
TL;DR: Fibres encapsulating primary pancreatic islet cells and transplanted through a microcatheter into the subrenal capsular space of diabetic mice normalized blood glucose concentrations for about two weeks and may find use as templates for the reconstruction of fibre-shaped functional tissues that mimic muscle fibres, blood vessels or nerve networks in vivo.
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Fluid shear triggers microvilli formation via mechanosensitive activation of TRPV6.
TL;DR: It is demonstrated that fluid shear stress (FSS), an external mechanical cue, serves as a trigger for microvilli formation in human placental trophoblastic cells and it is revealed that the transient receptor potential, vanilloid family type-6 (TRPV6) calcium ion channel plays a critical role in flow-induced Ca2+ influx and microVilli formation.
Journal ArticleDOI
Light generation of intracellular Ca(2+) signals by a genetically encoded protein BACCS.
Tomohiro Ishii,Koji Sato,Toshiyuki Kakumoto,Shigenori Miura,Kazushige Touhara,Shoji Takeuchi,Takao Nakata +6 more
TL;DR: A genetically engineered blue light-activated Ca2+ channel switch (BACCS) is reported, as an optogenetic tool for generatingCa2+ signals with a large dynamic range, and will be applicable to both in vitro and in vivo studies.
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ECM-based microchannel for culturing in vitro vascular tissues with simultaneous perfusion and stretch
TL;DR: It is suggested that the TG gelatin-based stretchable microfluidic system proves to be a useful tool for understanding the mechanisms of vascular tissue formation and mechanotransduction.
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Centrifuge-based step emulsification device for simple and fast generation of monodisperse picoliter droplets
TL;DR: In this paper, a step emulsification device is proposed for simple and fast generation of monodisperse water-in-oil (W/O) droplets with diameters ranging from 18 to 90 μm.