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Akihiko Okahara
Researcher at SANTEN PHARMACEUTICAL CO., LTD.
Publications - 9
Citations - 1040
Akihiko Okahara is an academic researcher from SANTEN PHARMACEUTICAL CO., LTD.. The author has contributed to research in topics: Arthritis & Matrix metalloproteinase. The author has an hindex of 7, co-authored 9 publications receiving 994 citations.
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Journal ArticleDOI
Development of Chronic Inflammatory Arthropathy Resembling Rheumatoid Arthritis in Interleukin 1 Receptor Antagonist–Deficient Mice
Reiko Horai,Shinobu Saijo,Hidetoshi Tanioka,Susumu Nakae,Katsuko Sudo,Akihiko Okahara,Toshimi Ikuse,Masahide Asano,Yoichiro Iwakura +8 more
TL;DR: It is shown that IL-1ra gene deficiency causes autoimmunity and joint-specific inflammation and suggested that IL -1ra is important in maintaining homeostasis of the immune system.
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TNF-α is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist–deficient mice
Reiko Horai,Akiko Nakajima,Katsuyoshi Habiro,Motoko Kotani,Susumu Nakae,Susumu Nakae,Taizo Matsuki,Aya Nambu,Shinobu Saijo,Hayato Kotaki,Katsuko Sudo,Katsuko Sudo,Akihiko Okahara,Hidetoshi Tanioka,Toshimi Ikuse,Naoto Ishii,Pamela L. Schwartzberg,Ryo Abe,Yoichiro Iwakura +18 more
TL;DR: The findings suggest that IL-1 receptor antagonist deficiency in T cells disrupts homeostasis of the immune system and that TNF-alpha plays an important role in activating T cells through induction of OX40.
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Effects of substance P and IGF-1 in corneal epithelial barrier function and wound healing in a rat model of neurotrophic keratopathy.
Takashi Nagano,Takashi Nagano,Masatsugu Nakamura,Masatsugu Nakamura,Katsuhiko Nakata,Takeshi Yamaguchi,Kenji Takase,Akihiko Okahara,Toshimi Ikuse,Teruo Nishida +9 more
TL;DR: A rat model of neurotrophic keratopathy, characterized by reduced tear secretion, loss of corneal sensation, impaired epithelial barrier function, and delayed epithelial wound healing, was established by trigeminal denervation.
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Involvement of leukotriene B4 in arthritis models
TL;DR: Results suggest that LTB4 may play an important role in arthritis models and inhibited the severity of collagen-induced arthritis and muramyl dipeptide (MDP)-induced hyperproliferation of synovial cells in vivo.
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Differential effects between marimastat, a TNF-α converting enzyme inhibitor, and anti-TNF-α antibody on murine models for sepsis and arthritis
Fumio Tsuji,Kenji Oki,Akihiko Okahara,Hiroshi Suhara,Takashi Yamanouchi,Minoru Sasano,Shiro Mita,Masato Horiuchi +7 more
TL;DR: The results suggest that cell surface TNF-α may be important in the pathogenesis of murine models for sepsis and arthritis.