Akihiro Hamasaki

TL;DR: GIP-reduced mice demonstrate that partial reduction of GIP does not extensively alter glucose tolerance, but it alleviates obesity and lessens the degree of insulin resistance under HFD conditions, suggesting a potential therapeutic value.

TL;DR: Because ammonia generated during fasting is toxic, SIRT5 protein might play a protective role by converting ammonia to non-toxic urea through deacetylation and activation of CPS1, a key enzyme of the urea cycle that catalyzes condensation of ammonia with bicarbonate to form carbamoyl phosphate.

TL;DR: Improvements in genotypic variation and ontogenetic change of Pn in rice under optimal conditions as a function of leaf nitrogen content per unit area (N) and stomatal conductance (g) are essential for an effective breeding of rice genotypes with increased Pn.

TL;DR: GPR120 is expressed abundantly in K cells of the upper small intestine and plays a critical role in lipid-induced GIP secretion.

TL;DR: A linear decline in endogenous insulin secretion over more than several decades of diabetes was confirmed by this cross-sectional study and the duration of diabetes exposure and BMI are thus major factors in beta-cell function in Japanese patients with type 2 diabetes.