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Akihiro Harada
Researcher at Osaka University
Publications - 89
Citations - 10514
Akihiro Harada is an academic researcher from Osaka University. The author has contributed to research in topics: Golgi apparatus & Endoplasmic reticulum. The author has an hindex of 36, co-authored 85 publications receiving 9550 citations. Previous affiliations of Akihiro Harada include University of Tokyo & Gunma University.
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Journal ArticleDOI
Randomization of Left–Right Asymmetry due to Loss of Nodal Cilia Generating Leftward Flow of Extraembryonic Fluid in Mice Lacking KIF3B Motor Protein
Shigenori Nonaka,Yosuke Tanaka,Yasushi Okada,Sen Takeda,Akihiro Harada,Yoshimitsu Kanai,Mizuho A. Kido,Nobutaka Hirokawa +7 more
TL;DR: The data suggest that KIF3B is essential for the left-right determination through intraciliary transportation of materials for ciliogenesis of motile primary cilia that could produce a gradient of putative morphogen along the left–right axis in the node.
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Transcriptional Induction of Mammalian ER Quality Control Proteins Is Mediated by Single or Combined Action of ATF6α and XBP1
Keisuke Yamamoto,Takashi Sato,Toshie Matsui,Masanori Sato,Tetsuya Okada,Hiderou Yoshida,Akihiro Harada,Kazutoshi Mori +7 more
TL;DR: It is demonstrated that ATF6alpha functions as a critical regulator of ER quality control proteins in mammalian cells, in marked contrast to worm and fly cells in which IRE1 is responsible.
Journal ArticleDOI
Altered microtubule organization in small-calibre axons of mice lacking tau protein
Akihiro Harada,Keiko Oguchi,Shigeo Okabe,Junko Kuno,Sumio Terada,T. Ohshima,Reiko Sato-Yoshitake,Yosuke Takei,Tetsuo Noda,Nobutaka Hirokawa +9 more
TL;DR: The results argue against the suggested role of tau in axonal elongation but confirm that it is crucial in the stabilization and organization of axonal microtubules in a certain type of axon.
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Targeted Disruption of Mouse Conventional Kinesin Heavy Chain kif5B, Results in Abnormal Perinuclear Clustering of Mitochondria
Yosuke Tanaka,Yoshimitsu Kanai,Yasushi Okada,Shigenori Nonaka,Sen Takeda,Akihiro Harada,Nobutaka Hirokawa +6 more
TL;DR: It is shown that kinesin is essential for mitochondrial and lysosomal dispersion rather than for the Golgi-to-ER traffic in these cells, and that KIF5B is associated with mitochondria.
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The cytoskeletal architecture of the presynaptic terminal and molecular structure of synapsin 1
TL;DR: Data derived via three different approaches suggest that synapsin 1 could be a main element of short linkages between actin filaments and synaptic vesicles, and between microtubules and synaptic Vesicles in the nerve terminals.