T
Toshie Matsui
Researcher at Kyoto University
Publications - 4
Citations - 5329
Toshie Matsui is an academic researcher from Kyoto University. The author has contributed to research in topics: Unfolded protein response & Endoplasmic reticulum. The author has an hindex of 4, co-authored 4 publications receiving 4892 citations.
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Journal ArticleDOI
XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor
TL;DR: The transcription factor XBP1, a target of ATF6, is identified as a mammalian substrate of such an unconventional mRNA splicing system and it is shown that only the spliced form of X BP1 can activate the UPR efficiently.
Journal ArticleDOI
Transcriptional Induction of Mammalian ER Quality Control Proteins Is Mediated by Single or Combined Action of ATF6α and XBP1
Keisuke Yamamoto,Takashi Sato,Toshie Matsui,Masanori Sato,Tetsuya Okada,Hiderou Yoshida,Akihiro Harada,Kazutoshi Mori +7 more
TL;DR: It is demonstrated that ATF6alpha functions as a critical regulator of ER quality control proteins in mammalian cells, in marked contrast to worm and fly cells in which IRE1 is responsible.
Journal ArticleDOI
A Time-Dependent Phase Shift in the Mammalian Unfolded Protein Response
Hiderou Yoshida,Toshie Matsui,Nobuko Hosokawa,Randal J. Kaufman,Kazuhiro Nagata,Kazutoshi Mori +5 more
TL;DR: It is shown here that degradation of misfolded glycoprotein substrates requires transcriptional induction of EDEM (ER degradation-enhancing alpha-mannosidase-like protein), and that this is mediated specifically by IRE1-XBP1 and not by ATF6.
Journal ArticleDOI
The cargo receptor ERGIC-53 is a target of the unfolded protein response.
TL;DR: Thapsigargin-induced upregulation of ERGIC-53 could be fully accounted for by the ATF6 pathway of UPR, and the results suggest that in mammalian cells the UPR also affects traffic from and beyond the ER.