Akihisa Kamataki

TL;DR: The data suggest that Wnt/LRP5 signaling contributes to the glucose-induced insulin secretion in the islets, which is also required for normal cholesterol and glucose metabolism.

TL;DR: Rat acyl-CoA synthetase (ACS) designated as ACS5 consists of 683 amino acids and is approximately 60% identical to the previously characterized ACS1 and ACS2, but differed in its preference for C16-C18 unsaturated fatty acids.

TL;DR: Analysis of plasma lipoproteins in mice lacking LRP5, apolipoprotein E (apoE), or both and histological examination revealed highly advanced arthrosclerosis, suggest that L RP5 mediates both apoE-dependent and apo E-independent catabolism of plasma lipid metabolism.

TL;DR: This newly identified HDL-binding protein designated GPI-anchored HDL- binding protein 1 (GPI-HBP1), was susceptible to phosphatidylinositol-specific phospholipase C treatment and binds HDL with high affinity (calculated K d = 2–3 μg/ml).

TL;DR: Fatty acid incorporation studies indicated that acyl-CoAs produced by MACS1 and Sa protein are utilized mainly for oxidation, whereas isobutyrate is the most preferred fatty acid among C2–C6 fatty acids for Sa protein.