J
Joji Yamamoto
Researcher at Tohoku University
Publications - 5
Citations - 1464
Joji Yamamoto is an academic researcher from Tohoku University. The author has contributed to research in topics: Gene & Promoter. The author has an hindex of 5, co-authored 5 publications receiving 1393 citations.
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Journal ArticleDOI
Activation of peroxisome proliferator-activated receptor δ induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome
Toshiya Tanaka,Joji Yamamoto,Satoshi Iwasaki,Hiroshi Asaba,Hiroki Hamura,Yukio Ikeda,Mitsuhiro Watanabe,Kenta Magoori,Ryoichi X. Ioka,Keisuke Tachibana,Yuichiro Watanabe,Yasutoshi Uchiyama,Koichi Sumi,Haruhisa Iguchi,Sadayoshi Ito,Takefumi Doi,Takao Hamakubo,Makoto Naito,Johan Auwerx,Masashi Yanagisawa,Tatsuhiko Kodama,Juro Sakai +21 more
TL;DR: Analysis of rat L6 myotubes treated with the PPARδ subtype-selective agonist, GW501516, by the Affymetrix oligonucleotide microarrays revealed that PPAR Δ is pivotal to control the program for fatty acid oxidation in the skeletal muscle, thereby ameliorating obesity and insulin resistance through its activation in obese animals.
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Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion
Takahiro Fujino,Hiroshi Asaba,Man Jong Kang,Yukio Ikeda,Hideyuki Sone,Shinji Takada,Shinji Takada,Dong Ho Kim,Ryoichi X. Ioka,Masao Ono,Hiroko Tomoyori,Minoru Okubo,Toshio Murase,Akihisa Kamataki,Joji Yamamoto,Kenta Magoori,Sadao Takahashi,Yoshiharu Miyamoto,Hisashi Oishi,Masato Nose,Mitsuyo Okazaki,Shinichi Usui,Katsumi Imaizumi,Masashi Yanagisawa,Juro Sakai,Tokuo T. Yamamoto +25 more
TL;DR: The data suggest that Wnt/LRP5 signaling contributes to the glucose-induced insulin secretion in the islets, which is also required for normal cholesterol and glucose metabolism.
Journal ArticleDOI
A Krüppel-like factor KLF15 Contributes Fasting-induced Transcriptional Activation of Mitochondrial Acetyl-CoA Synthetase Gene AceCS2
Joji Yamamoto,Yukio Ikeda,Haruhisa Iguchi,Takahiro Fujino,Toshiya Tanaka,Hiroshi Asaba,Satoshi Iwasaki,Ryoichi X. Ioka,Izumi W. Kaneko,Kenta Magoori,Sadao Takahashi,Toshiyuki Mori,Hiroshi Sakaue,Tatsuhiko Kodama,Masashi Yanagisawa,Tokuo T. Yamamoto,Sadayoshi Ito,Juro Sakai +17 more
TL;DR: It is shown that the combination of KLF15 and Sp1 resulted in a synergistic activation of the AceCS2 promoter, and Krüppel-like factor 15 (KLF15) plays a key role in the trans-activation of the ACECS2 gene.
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Fasting-Induced Hypothermia and Reduced Energy Production in Mice Lacking Acetyl-CoA Synthetase 2
Iori Sakakibara,Takahiro Fujino,Makoto Ishii,Toshiya Tanaka,Tatsuo Shimosawa,Shinji Miura,Wei Zhang,Yuka Tokutake,Joji Yamamoto,Mutsumi Awano,Satoshi Iwasaki,Toshiyuki Motoike,Masashi Okamura,Masashi Okamura,Takeshi Inagaki,Kiyoshi Kita,Osamu Ezaki,Makoto Naito,Tomoyuki Kuwaki,Shigeru Chohnan,Tokuo T. Yamamoto,Robert E. Hammer,Tatsuhiko Kodama,Masashi Yanagisawa,Juro Sakai +24 more
TL;DR: It is demonstrated that activation of acetate by AceCS2 plays a pivotal role in thermogenesis, especially under low-glucose or ketogenic conditions, and is crucially required for survival.
Journal ArticleDOI
Transcriptional regulation of the murine acetyl-CoA synthetase 1 gene through multiple clustered binding sites for sterol regulatory element-binding proteins and a single neighboring site for Sp1.
Yukio Ikeda,Joji Yamamoto,Masashi Okamura,Takahiro Fujino,Sadao Takahashi,Kazuhisa Takeuchi,Timothy F. Osborne,Tokuo T. Yamamoto,Sadayoshi Ito,Juro Sakai +9 more
TL;DR: The molecular mechanisms directing the sterol-regulated expression of murine Ace CS1 are described by cloning and functional studies of the 5′-flanking region of the AceCS1 gene.