A
Akina Ishii
Researcher at University of Tokyo
Publications - 5
Citations - 927
Akina Ishii is an academic researcher from University of Tokyo. The author has contributed to research in topics: Immune system & Immunoglobulin E. The author has an hindex of 4, co-authored 5 publications receiving 862 citations.
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Journal ArticleDOI
IL-33 is a crucial amplifier of innate rather than acquired immunity
Keisuke Oboki,Tatsukuni Ohno,Naoki Kajiwara,Ken Arae,Hideaki Morita,Akina Ishii,Aya Nambu,Takaya Abe,Hiroshi Kiyonari,Kenji Matsumoto,Katsuko Sudo,Ko Okumura,Hirohisa Saito,Susumu Nakae +13 more
TL;DR: It is found that IL-1, but not IL-33, played a substantial role in induction of T cell-mediated type IV hypersensitivity such as contact and delayed-type hypersensitivity and autoimmune diseases such as experimental autoimmune encephalomyelitis andIL-33 was important for innate-type mucosal immunity in the lungs and gut.
Journal ArticleDOI
Dcir deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells.
Noriyuki Fujikado,Shinobu Saijo,Tomo Yonezawa,Kazusuke Shimamori,Akina Ishii,Sho Sugai,Hayato Kotaki,Hayato Kotaki,Katsuko Sudo,Katsuko Sudo,Masato Nose,Yoichiro Iwakura +11 more
TL;DR: It is found that aged Dcir−/− mice spontaneously develop sialadenitis and enthesitis associated with elevated serum autoantibodies, which indicates that D cir is a negative regulator of DC expansion and has a crucial role in maintaining the homeostasis of the immune system.
Journal ArticleDOI
Epithelial Cell-Derived IL-25, but Not Th17 Cell-Derived IL-17 or IL-17F, Is Crucial for Murine Asthma
Maho Suzukawa,Hideaki Morita,Aya Nambu,Ken Arae,Eri Shimura,Akiko Shibui,Sachiko Yamaguchi,Keigo Suzukawa,Wakako Nakanishi,Keisuke Oboki,Naoki Kajiwara,Tatsukuni Ohno,Akina Ishii,Heinrich Körner,Daniel J. Cua,Hajime Suto,Takayuki Yoshimoto,Yoichiro Iwakura,Tatsuya Yamasoba,Ken Ohta,Katsuko Sudo,Hirohisa Saito,Ko Okumura,David H. Broide,Kenji Matsumoto,Susumu Nakae +25 more
TL;DR: Airway structural cell- derived IL-25—rather than Th17 cell-derived IL- 17A and IL-17F—is responsible for induction of local inflammation by promoting activation of lung epithelial cells and eosinophils in the elicitation phase of Th2-type/eosinophile airway inflammation.
Journal ArticleDOI
Development of IL-17-mediated delayed-type hypersensitivity is not affected by down-regulation of IL-25 expression.
Akina Ishii,Keisuke Oboki,Aya Nambu,Hideaki Morita,Tatsukuni Ohno,Naoki Kajiwara,Ken Arae,Hajime Sudo,Ko Okumura,Hirohisa Saito,Susumu Nakae,Susumu Nakae +11 more
TL;DR: IL-25 is not essential for differentiation of Th1, Th2 and Th17 cells in the sensitization phase or induction of local inflammation in the elicitation phase of the mBSA-induced DTH reaction.
Journal ArticleDOI
Amphiregulin Is Not Essential for Ovalbumin-Induced Acute Airway Inflammation in Mice
Naoki Kajiwara,Keisuke Oboki,Tatsukuni Ohno,Akina Ishii,Susan W. Sunnarborg,Ko Okumura,Hirohisa Saito,Susumu Nakae +7 more
TL;DR: Amphiregulin is not essential for induction of acute airway inflammation by OVA in mice, and the role of AR in the pathogenesis of asthma is elucidated.