A
Akio Inoue
Researcher at National Institute of Advanced Industrial Science and Technology
Publications - 5
Citations - 224
Akio Inoue is an academic researcher from National Institute of Advanced Industrial Science and Technology. The author has contributed to research in topics: Estrogen & Gene expression profiling. The author has an hindex of 4, co-authored 5 publications receiving 219 citations.
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Using a customized DNA microarray for expression profiling of the estrogen-responsive genes to evaluate estrogen activity among natural estrogens and industrial chemicals.
Shunichi Terasaka,Yukie Aita,Akio Inoue,Shin Ichi Hayashi,Michiko Nishigaki,Kazuhiko Aoyagi,Hiroki Sasaki,Yuko Wada-Kiyama,Yasuo Sakuma,Shuichi Akaba,Junko Tanaka,Hideko Sone,Junzo Yonemoto,Masao Tanji,Ryoiti Kiyama +14 more
TL;DR: A DNA microarray to evaluate the estrogen activity of natural estrogens and industrial chemicals was developed and showed more sensitivity for dioxin and methoxychlor than other bioassays used for detecting estrogen activity.
Journal ArticleDOI
Prediction of prognosis of estrogen receptor-positive breast cancer with combination of selected estrogen-regulated genes.
Nobuyuki Yoshida,Yoko Omoto,Akio Inoue,Hidetaka Eguchi,Yasuhito Kobayashi,Masafumi Kurosumi,Shigehira Saji,Kimito Suemasu,Tomoki Okazaki,Kei Nakachi,Toshiro Fujita,Shin Ichi Hayashi +11 more
TL;DR: This study has identified new candidate ERGs for prediction of prognosis, and it is suggested that combined assessment of the expression levels of these ERGs will contribute to the clinically useful stratification of ER‐positive breast cancer patients.
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Estrogen and growth factor signaling pathway: basic approaches for clinical application.
TL;DR: The observations suggest that the constitutively activated MAP kinase-signaling pathway in endometrial cancer cells might enhance the transcriptional activity of ERalpha via phosphorylation of AF-1 domain, which may cause the growth stimulative effect of tamoxifen on the endometrium.
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A reporter gene assay for evaluation of tissue-specific responses to estrogens based on the differential use of promoters A to F of the human estrogen receptor α gene
TL;DR: A reporter gene assay for evaluating and monitoring estrogen activities by estrogen-like compounds and xenoestrogens, which is based on the promoters from the human estrogen receptor alpha (ERalpha) gene is reported.
Journal ArticleDOI
Expression profiling of the estrogen responsive genes for evaluation of estrogen activity among natural estrogens and industrial chemicals using a customized DNA microarray
Shunichi Terasaka,Aita Aita,Akio Inoue,Shin Ichi Hayashi,Michiko Nishigaki,Kazuhiko Aoyagi,Hiroki Sasaki,Yuko Wada-Kiyama,Yasuo Sakuma,Shuichi Akaba,Junko Tanaka,Hideko Sone,Junzo Yonemoto,Masao Tanji,Ryoiti Kiyama +14 more