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Akira Endo
Researcher at Tokyo University of Agriculture
Publications - 102
Citations - 6938
Akira Endo is an academic researcher from Tokyo University of Agriculture. The author has contributed to research in topics: Reductase & Enzyme. The author has an hindex of 35, co-authored 101 publications receiving 6651 citations.
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Journal ArticleDOI
Ml-236a, ml-236b, and ml-236c, new inhibitors of cholesterogenesis produced by penicillium citrinum
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Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme a reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity
TL;DR: The experiments reported in this paper demonstrate that MG236A and ML-236B inhibit specifically 3-hydroxy-3-methylglutaryl (HMG)CoA reductase (EC 1 .I .1.34), the rate-limiting enzyme in cholesterol synthetic pathway, without affecting the rest of the enzymes involved in this pathway, and that the inhibition is competitive with respect to the substrate HMG-CoA.
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Monacolin k, a new hypocholesterolemic agent produced by a monascus species
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Inhibition of Cholesterol Synthesis in vitro and in vivo by ML-236A and ML-236B, Competitive Inhibitors of 3-Hydroxy-3-methylglutaryl-Coenzyme A Reductase
TL;DR: Sterol synthesis in the liver was far more strongly inhibited than that in other organs tested including kidney, lung, adrenal, spleen, and testis and strongly suggest that hypocholesterolemic activity of ML-236A and ML- 236B is owing largely to specific inhibition of hepatic cholesterol synthesis.