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Akira Ishiwata
Researcher at Jichi Medical University
Publications - 20
Citations - 788
Akira Ishiwata is an academic researcher from Jichi Medical University. The author has contributed to research in topics: Transplantation & Bone marrow. The author has an hindex of 15, co-authored 19 publications receiving 744 citations. Previous affiliations of Akira Ishiwata include Mitsubishi.
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Journal ArticleDOI
Severe secondary deficiency of von Willebrand factor-cleaving protease (ADAMTS13) in patients with sepsis-induced disseminated intravascular coagulation: its correlation with development of renal failure.
Tomoko Ono,Jun Mimuro,Seiji Madoiwa,Kenji Soejima,Yuji Kashiwakura,Akira Ishiwata,Katsuhiro Takano,Tsukasa Ohmori,Yoichi Sakata +8 more
TL;DR: Deep molecular weight forms of ADAMTS13 were found in the plasma of patients with sepsis-induced DIC, suggesting that the deficiency of ADamTS13 was partially caused by its cleavage by proteases in addition to decreased synthesis in the liver.
Journal ArticleDOI
Minimizing the inhibitory effect of neutralizing antibody for efficient gene expression in the liver with adeno-associated virus 8 vectors.
Jun Mimuro,Hiroaki Mizukami,Shuji Hishikawa,Tomokazu Ikemoto,Akira Ishiwata,Asuka Sakata,Tsukasa Ohmori,Seiji Madoiwa,Fumiko Ono,Keiya Ozawa,Yoichi Sakata +10 more
TL;DR: The results suggest that portal vein-directed vector delivery strategies with flushing to remove blood are efficacious for minimizing the inhibitory effect of anti-AAV antibodies.
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Efficient expression of a transgene in platelets using simian immunodeficiency virus-based vector harboring glycoprotein Ibα promoter: in vivo model for platelet-targeting gene therapy
Tsukasa Ohmori,Jun Mimuro,Katsuhiro Takano,Seiji Madoiwa,Yuji Kashiwakura,Akira Ishiwata,Masanori Niimura,Katsuyuki Mitomo,Toshiaki Tabata,Mamoru Hasegawa,Keiya Ozawa,Yoichi Sakata +11 more
TL;DR: Platelet‐targeting gene therapy using SIV vectors appears to be promising for gene therapy approaches toward not only inherited platelet diseases but also other hemorrhagic disorders such as hemophilia A.
Journal ArticleDOI
Liver-restricted expression of the canine factor VIII gene facilitates prevention of inhibitor formation in factor VIII-deficient mice.
Akira Ishiwata,Jun Mimuro,Hiroaki Mizukami,Yuji Kashiwakura,Katsuhiro Takano,Tsukasa Ohmori,Seiji Madoiwa,Keiya Ozawa,Yoichi Sakata +8 more
TL;DR: Gene therapy for hemophilia A with adeno‐associated virus (AAV) vectors involves difficulties in the efficient expression of factor VIII (FVIII) and in antibody formation against transgene‐derived FVIII.
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Porcine model of hemophilia A.
Yuji Kashiwakura,Jun Mimuro,Akira Onishi,Masaki Iwamoto,Seiji Madoiwa,Daiichiro Fuchimoto,Shunichi Suzuki,M. Suzuki,Shoichiro Sembon,Akira Ishiwata,Atsushi Yasumoto,Asuka Sakata,Tsukasa Ohmori,Michiko Hashimoto,Satoko Yazaki,Yoichi Sakata +15 more
TL;DR: The data suggest that the hemophilia A pig is a severe hemophile A animal model for studying not only hemophili A gene therapy but also the next generation recombinant coagulation factors, such as recombinant factor VIII variants with a slower clearance rate.