T
Tsukasa Ohmori
Researcher at Jichi Medical University
Publications - 122
Citations - 3670
Tsukasa Ohmori is an academic researcher from Jichi Medical University. The author has contributed to research in topics: Sphingosine-1-phosphate & Sphingosine. The author has an hindex of 29, co-authored 112 publications receiving 3304 citations. Previous affiliations of Tsukasa Ohmori include University of Tennessee Health Science Center & University of Tokyo.
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Journal ArticleDOI
Severe secondary deficiency of von Willebrand factor-cleaving protease (ADAMTS13) in patients with sepsis-induced disseminated intravascular coagulation: its correlation with development of renal failure.
Tomoko Ono,Jun Mimuro,Seiji Madoiwa,Kenji Soejima,Yuji Kashiwakura,Akira Ishiwata,Katsuhiro Takano,Tsukasa Ohmori,Yoichi Sakata +8 more
TL;DR: Deep molecular weight forms of ADAMTS13 were found in the plasma of patients with sepsis-induced DIC, suggesting that the deficiency of ADamTS13 was partially caused by its cleavage by proteases in addition to decreased synthesis in the liver.
Journal ArticleDOI
Sphingosine 1-phosphate as a major bioactive lysophospholipid that is released from platelets and interacts with endothelial cells.
Yutaka Yatomi,Tsukasa Ohmori,Tsukasa Ohmori,Ge Rile,Ge Rile,Fuminori Kazama,Fuminori Kazama,Hirotaka Okamoto,Hirotaka Okamoto,Takamitsu Sano,Takamitsu Sano,Kaneo Satoh,Kaneo Satoh,Shoji Kume,Shoji Kume,Gabor Tigyi,Gabor Tigyi,Yasuyuki Igarashi,Yasuyuki Igarashi,Yukio Ozaki,Yukio Ozaki +20 more
TL;DR: Sph-1-P, rather than LPA, is a major bioactive lysophospholipid that is released from platelets and interacts with endothelial cells, under the conditions in which critical platelet-endothelial interactions occur.
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IL-1α induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs.
Satoshi Nishimura,Satoshi Nishimura,Satoshi Nishimura,Mika Nagasaki,Shinji Kunishima,Akira Sawaguchi,Asuka Sakata,Hiroyasu Sakaguchi,Tsukasa Ohmori,Ichiro Manabe,Joseph E. Italiano,Tomiko Ryu,Naoya Takayama,Issei Komuro,Takashi Kadowaki,Koji Eto,Ryozo Nagai +16 more
TL;DR: An alternative pathway triggering enhanced platelet release from bone marrow megakaryocytes via a rupture-based mechanism is regulated by IL-1α in response to acute platelet requirements.
Journal ArticleDOI
Sphingosine 1-phosphate: synthesis and release
TL;DR: In this paper, it is shown that platelets are an important source for extracellular sphingosine 1-phosphate (Sph-1-P) synthesis.
Journal ArticleDOI
Essential roles of sphingosine 1-phosphate/S1P1 receptor axis in the migration of neural stem cells toward a site of spinal cord injury.
Atsushi Kimura,Tsukasa Ohmori,Ryunosuke Ohkawa,Seiji Madoiwa,Jun Mimuro,Takashi Murakami,Eiji Kobayashi,Yuichi Hoshino,Yutaka Yatomi,Yoichi Sakata +9 more
TL;DR: It is found that sphingosine 1‐phosphate (Sph‐1‐P), a physiological lysophospholipid mediator, had a potent chemoattractant activity for NSPCs, in which, of Sph‐ 1‐P receptors, S1P1 was abundantly expressed.