A
Akira Ohtake
Researcher at Saitama Medical University
Publications - 169
Citations - 4474
Akira Ohtake is an academic researcher from Saitama Medical University. The author has contributed to research in topics: Mitochondrial respiratory chain & Mitochondrial disease. The author has an hindex of 33, co-authored 159 publications receiving 3634 citations. Previous affiliations of Akira Ohtake include Kumamoto University & Institute of Medical Science.
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Journal ArticleDOI
Analysis of the assembly profiles for mitochondrial- and nuclear-DNA-encoded subunits into complex I.
Michael Lazarou,Matthew McKenzie,Akira Ohtake,Akira Ohtake,David R. Thorburn,Michael T. Ryan +5 more
TL;DR: A mechanism of complex I biogenesis involving two complementary processes, synthesis of mtDNA-encoded subunits to seed de novo assembly and exchange of preexisting subunits with newly imported ones to maintain complex I homeostasis is pointed to.
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A Comprehensive Genomic Analysis Reveals the Genetic Landscape of Mitochondrial Respiratory Chain Complex Deficiencies.
Masakazu Kohda,Yoshimi Tokuzawa,Yoshihito Kishita,Hiromi Nyuzuki,Yohsuke Moriyama,Yosuke Mizuno,Tomoko Hirata,Yukiko Yatsuka,Yzumi Yamashita-Sugahara,Yutaka Nakachi,Hidemasa Kato,Akihiko Okuda,Shunsuke Tamaru,Nurun Nahar Borna,Kengo Banshoya,Toshiro Aigaki,Yukiko Sato-Miyata,Kohei Ohnuma,Tsutomu Suzuki,Asuteka Nagao,Hazuki Maehata,Fumihiko Matsuda,Koichiro Higasa,Masao Nagasaki,Jun Yasuda,Masayuki Yamamoto,Takuya Fushimi,Masaru Shimura,Keiko Kaiho-Ichimoto,Hiroko Harashima,Taro Yamazaki,Masato Mori,Kei Murayama,Akira Ohtake,Yasushi Okazaki +34 more
TL;DR: These approaches enhance the ability to identify pathogenic gene mutations in patients with biochemically defined mitochondrial respiratory chain complex deficiencies in clinical settings and will improve patient care of this complex disorder.
Journal ArticleDOI
Constitutively activated ALK2 and increased SMAD1/5 cooperatively induce bone morphogenetic protein signaling in fibrodysplasia ossificans progressiva
Toru Fukuda,Masakazu Kohda,Kazuhiro Kanomata,Junya Nojima,Atsushi Nakamura,Jyunji Kamizono,Yasuo Noguchi,Kiyofumi Iwakiri,Takeo Kondo,Junichi Kurose,Ken-ichi Endo,Takeshi Awakura,Jun Ichi Fukushi,Yasuharu Nakashima,Yasuharu Nakashima,Tomohiro Chiyonobu,Akira Kawara,Yoshihiro Nishida,Ikuo Wada,Masumi Akita,Tetsuo Komori,Konosuke Nakayama,Akira Nanba,Yuichi Maruki,Tetsuya Yoda,Hiroshi Tomoda,Hiroshi Tomoda,Paul B. Yu,Eileen M. Shore,Frederick S. Kaplan,Kohei Miyazono,Kohei Miyazono,Masaru Matsuoka,Kenji Ikebuchi,Akira Ohtake,Hiromi Oda,Eijiro Jimi,Ichiro Owan,Yasushi Okazaki,Takenobu Katagiri +39 more
TL;DR: The findings suggest that the heterotopic bone formation in FOP may be induced by a constitutively activated BMP receptor signaling through Smad1 or Smad5, andGene transfer of Smad7 or inhibition of type I receptors with dorsomorphin may represent strategies for blocking the activity induced by ALK2(R206H) in Fop.
Journal ArticleDOI
NDUFS6 mutations are a novel cause of lethal neonatal mitochondrial complex I deficiency
Denise M. Kirby,Renato Salemi,Canny Sugiana,Canny Sugiana,Akira Ohtake,Akira Ohtake,Lee Parry,Katrina M. Bell,Edwin P. Kirk,Avihu Boneh,Avihu Boneh,Robert W. Taylor,Hans Henrik M. Dahl,Hans Henrik M. Dahl,Michael T. Ryan,David R. Thorburn,David R. Thorburn +16 more
TL;DR: An integrated approach to gene identification offers promise for identifying other unknown causes of respiratory chain disorders.
Journal ArticleDOI
Mutations of the mitochondrial ND1 gene as a cause of MELAS
Denise M. Kirby,Denise M. Kirby,Robert McFarland,Akira Ohtake,Akira Ohtake,Christopher J.R. Dunning,Michael T. Ryan,Callum Wilson,David Ketteridge,Douglass M. Turnbull,David R. Thorburn,David R. Thorburn,Robert W. Taylor +12 more
TL;DR: Three unrelated patients with MELAS and isolated complex I deficiency in skeletal muscle and cultured fibroblasts are reported due to previously unreported mutations in the MTND1 gene, confirming a crucial role for the ND1 subunit in the assembly of complex I holoenzyme.