A
Akitoshi Nagasaki
Researcher at Kumamoto University
Publications - 32
Citations - 1564
Akitoshi Nagasaki is an academic researcher from Kumamoto University. The author has contributed to research in topics: Multiple myeloma & Nitric oxide. The author has an hindex of 19, co-authored 32 publications receiving 1539 citations.
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Molecular cloning of cDNA for nonhepatic mitochondrial arginase (arginase II) and comparison of its induction with nitric oxide synthase in a murine macrophage-like cell line
Tomomi Gotoh,Takashi Sonoki,Akitoshi Nagasaki,Kazutoyo Terada,Masaki Takiguchi,Masataka Mori +5 more
TL;DR: Arginase II mRNA was coinduced with nitric oxide synthase mRNA in murine macrophage‐like RAW 264.7 cells by lipopolysaccharide and enhanced by dexamethasone and dibutyryl cAMP, and was prevented by interferon‐γ.
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Coinduction of Nitric-oxide Synthase and Arginase I in Cultured Rat Peritoneal Macrophages and Rat Tissues in Vivo by Lipopolysaccharide
Takashi Sonoki,Akitoshi Nagasaki,Tomomi Gotoh,Masaki Takiguchi,Motohiro Takeya,Hiromitsu Matsuzaki,Masataka Mori +6 more
TL;DR: Arginase I appears to have an important role in down-regulating nitric oxide synthesis in murine macrophages by decreasing the availability of arginine, and the induction of arkinase I is mediated by C/EBPβ.
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Activated protein C prevents endotoxin-induced hypotension in rats by inhibiting excessive production of nitric oxide
Hirotaka Isobe,Kenji Okajima,Mitsuhiro Uchiba,Akio Mizutani,Naoaki Harada,Akitoshi Nagasaki,Kazutoshi Okabe +6 more
TL;DR: In this article, activated protein C (APC), a physiological anticoagulant, inhibits TNF-α production, which might prevent endotoxin (ET)-induced hypotension by inhibiting excessive production of NO.
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Coinduction of Nitric Oxide Synthase, Argininosuccinate Synthetase, and Argininosuccinate Lyase in Lipopolysaccharide-treated Rats: RNA BLOT, IMMUNOBLOT, AND IMMUNOHISTOCHEMICAL ANALYSES
Akitoshi Nagasaki,Tomomi Gotoh,Motohiro Takeya,Yingjie Yu,Masaki Takiguchi,Hiromitsu Matsuzaki,Kiyoshi Takatsuki,Masataka Mori +7 more
TL;DR: As iNOS, AS, and AL were coinduced in rat tissues and cells, citrulline-arginine recycling seems to be important in NO synthesis under the conditions of stimulation.
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Regulation of the genes for arginase isoforms and related enzymes in mouse macrophages by lipopolysaccharide
TL;DR: Results indicate that the genes for the two arginase isoforms are regulated differentially in the regulation of nitric oxide production and in polyamine synthesis.