M
Motohiro Takeya
Researcher at Kumamoto University
Publications - 250
Citations - 15305
Motohiro Takeya is an academic researcher from Kumamoto University. The author has contributed to research in topics: Macrophage & Monocyte. The author has an hindex of 64, co-authored 249 publications receiving 14401 citations. Previous affiliations of Motohiro Takeya include University of Texas Southwestern Medical Center & Chugai Pharmaceutical Co..
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Journal ArticleDOI
A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection
Hiroshi Suzuki,Hiroshi Suzuki,Yukiko Kurihara,Motohiro Takeya,Nobuo Kamada,Motoyukl Kataoka,Kou-ichi Jishage,Otoya Ueda,Hisashl Sakaguchi,Takayuki Higashi,Tsukasa Suzuki,Yoshiaki Takashima,Yoshiki Kawabe,Yoshiki Kawabe,Osamu Cynshi,Youichiro Wada,Makoto Honda,Hiroki Kurihara,Hiroyuki Aburatani,Takefumi Doi,Akiyo Matsumoto,Sadahiro Azuma,Tetsuo Noda,Yutaka Toyoda,Hiroshige Itakura,Yoshio Yazaki,Seikoh Horiuchi,Kiyoshi Takahashi,J. Kar Kruijt,Theo J.C. Van Berkel,Urs P. Steinbrecher,Shun Ishibashi,Nobuyo Maeda,Siamon Gordon,Tatsuhiko Kodama +34 more
TL;DR: It is shown that targeted disruption of the MSR-A gene in mice results in a reduction in the size of atherosclerotic lesions in an animal deficient in apolipoprotein E, indicating that MSr-A may play a part in host defence against pathogens.
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DC-STAMP is essential for cell–cell fusion in osteoclasts and foreign body giant cells
Mitsuru Yagi,Takeshi Miyamoto,Yumi Sawatani,Katsuya Iwamoto,Naobumi Hosogane,Nobuyuki Fujita,Kozo Morita,Ken Ninomiya,Toru Suzuki,Kana Miyamoto,Yuichi Oike,Motohiro Takeya,Yoshiaki Toyama,Toshio Suda +13 more
TL;DR: An essential regulator of osteoclast and macrophage cell fusion, DC-STAMP, is identified and an essential role of osteOClast multinucleation in bone homeostasis is identified.
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Deletion of LOX-1 Reduces Atherogenesis in LDLR Knockout Mice Fed High Cholesterol Diet
Jawahar L. Mehta,Nobuhito Sanada,Chang Ping Hu,Jiawei Chen,Abhijit Dandapat,Fumiaki Sugawara,Hiroo Satoh,Kazuhiko Inoue,Yosuke Kawase,Kou Ichi Jishage,Hiroshi Suzuki,Motohiro Takeya,Laura K. Schnackenberg,Richard D. Beger,Paul L. Hermonat,Maria Thomas,Tatsuya Sawamura +16 more
TL;DR: Generation of LOX-1 knockout mice in which binding of oxLDL to aortic endothelium was reduced and endothelia-dependent vasorelaxation preserved after treatment withOxLDL sustains endothelial function leading to a reduction in atherogenesis in association with reduction in proinflammatory and prooxidant signals.
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Histopathologic pulmonary changes from mechanical ventilation at high peak airway pressures
TL;DR: The histopathologic pulmonary changes induced by mechanical pulmonary ventilation with a high peak airway pressure and a large tidal volume in healthy baby pigs were investigated, finding prominent organized alveolar exudate in addition to lesions was indistinguishable from the clinical late stage of ARDS.
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Increased Adiponectin Secretion by Highly Purified Eicosapentaenoic Acid in Rodent Models of Obesity and Human Obese Subjects
Michiko Itoh,Takayoshi Suganami,Noriko Satoh,Kanami Tanimoto-Koyama,Xunmei Yuan,Miyako Tanaka,Hiroyuki Kawano,Takashi Yano,Seiichiro Aoe,Motohiro Takeya,Akira Shimatsu,Hideshi Kuzuya,Yasutomi Kamei,Yoshihiro Ogawa +13 more
TL;DR: It is demonstrated that EPA increases adiponectin secretion in rodent models of obesity and human obese subjects, possibly through the improvement of the inflammatory changes in obese adipose tissue.