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Ákos Rácz
Researcher at Semmelweis University
Publications - 17
Citations - 295
Ákos Rácz is an academic researcher from Semmelweis University. The author has contributed to research in topics: Conformational isomerism & Docking (molecular). The author has an hindex of 10, co-authored 17 publications receiving 266 citations. Previous affiliations of Ákos Rácz include Hungarian Academy of Sciences.
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Journal ArticleDOI
Binding mode analysis and enrichment studies on homology models of the human histamine H4 receptor
TL;DR: It is concluded that the ligand used in the model building process can significantly influence the efficacy of virtual screening and suggest a role of Thr323 in ligand binding and presumably also in receptor activation.
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The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms.
Tibor Kovács,Viktor Billes,Marcell Komlós,Bernadette Hotzi,Anna Manzéger,Anna Tarnóci,Diana Papp,Fanni Szikszai,Janka Szinyákovics,Ákos Rácz,Béla Noszál,Szilvia Veszelka,Fruzsina R. Walter,Mária A. Deli,László Hackler,Róbert Alföldi,Orsolya Huzian,László G. Puskás,Hanna Liliom,Krisztián Tárnok,Katalin Schlett,Adrienn Borsy,Ervin Welker,Attila L. Kovács,Zsolt Padar,Attila Erdős,Ádám Légrádi,Annamária Bjelik,Karoly Gulya,Balázs Gulyás,Balázs Gulyás,Balázs Gulyás,Tibor Vellai +32 more
TL;DR: AUTEN-99 appears to effectively penetrate through the blood-brain barrier, and impedes the progression of neurodegenerative symptoms in Drosophila models of Parkinson's and Huntington’s diseases, and increases the survival of isolated neurons under normal and oxidative stress-induced conditions.
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Lipophilicity of vinpocetine and related compounds characterized by reversed-phase thin-layer chromatography.
TL;DR: Conclusions on structure-lipophilicity relationships were drawn in terms of ring anellation, character and length of side chain, conformational preferences and moiety-solvent interactions, also supported by molecular mechanics studies.
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Characterization of aspartame-cyclodextrin complexation
TL;DR: The seven-membered beta-cyclodextrin and its derivatives have been found to be the most suitable host molecules for complexation and the purity of the CD enhanced the complexation while the degree of substitution did not provide obvious consequences.
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Equilibrium and structural characterization of ofloxacin–cyclodextrin complexation
Gergő Tóth,Réka Mohácsi,Ákos Rácz,Aura Rusu,Peter Horvath,Lajos Szente,Szabolcs Béni,Béla Noszál +7 more
TL;DR: The enantiomer-specific characterization of ofloxacin–cyclodextrin complexes was carried out by a set of complementary analytical techniques, verifying that SP greatly affects the complex stability.