M
Matthias Amrein
Researcher at University of Calgary
Publications - 94
Citations - 4017
Matthias Amrein is an academic researcher from University of Calgary. The author has contributed to research in topics: Pulmonary surfactant & Scanning tunneling microscope. The author has an hindex of 33, co-authored 91 publications receiving 3556 citations. Previous affiliations of Matthias Amrein include ETH Zurich & École Polytechnique Fédérale de Lausanne.
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Journal ArticleDOI
Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity
Tracy L. Flach,Gilbert Ng,Aswin Hari,Melanie D. Desrosiers,Ping Zhang,Sandra Ward,Mark E. Seamone,Akosua Vilaysane,Ashley D. Mucsi,Yin Fong,Elmar J. Prenner,Chang-Chun Ling,Jürg Tschopp,Daniel A. Muruve,Matthias Amrein,Yan Shi +15 more
TL;DR: This study reports that, independent of inflammasome and membrane proteins, alum binds dendritic cell (DC) plasma membrane lipids with substantial force and proposes that alum triggers DC responses by altering membrane lipid structures.
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Receptor-Independent, Direct Membrane Binding Leads to Cell-Surface Lipid Sorting and Syk Kinase Activation in Dendritic Cells
Gilbert Ng,Karan Sharma,Sandra Ward,Melanie D. Desrosiers,Leslie A. Stephens,W. Michael Schoel,Tonglei Li,Clifford A. Lowell,Chang-Chun Ling,Matthias Amrein,Yan Shi +10 more
TL;DR: Atomic force microscopy observations suggest a mechanism whereby immune cell activation can be triggered by solid structures via membrane lipid alteration without the requirement for specific cell-surface receptors, and a testable hypothesis for crystal-associated arthropathies, inflammation, and adjuvanticity.
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The structure of a model pulmonary surfactant as revealed by scanning force microscopy.
TL;DR: It is demonstrated that some of the matter of the model pulmonary surfactant can move in and out of the active monolayer, to keep the surface tension of the alveolar air/water interface constantly low over the range of area encountered upon breathing.
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The Sendai virus nucleocapsid exists in at least four different helical states.
TL;DR: In this article, the authors used image reconstruction techniques on an averaged data set from eight negatively stained nucleocapsids to produce a 3D reconstruction at 2.4nm resolution of the structure in one of the 5.3-nm pitch states.
Journal ArticleDOI
Identification and treatment of the Staphylococcus aureus reservoir in vivo
Bas G.J. Surewaard,Justin F. Deniset,Franz J. Zemp,Matthias Amrein,Michael Otto,John Conly,Abdelwahab Omri,Robin M. Yates,Paul Kubes +8 more
TL;DR: It is shown that methicillin-resistant Staphylococcus aureus survive and proliferate inside Kupffer cells, which is resistant to neutrophil-killing and antibiotics treatment and, when released into the circulation, can infect other organs.