A
Akshay A. D’Cruz
Researcher at Boston Children's Hospital
Publications - 16
Citations - 834
Akshay A. D’Cruz is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Programmed cell death & Inflammation. The author has an hindex of 8, co-authored 13 publications receiving 625 citations. Previous affiliations of Akshay A. D’Cruz include University of Melbourne & Walter and Eliza Hall Institute of Medical Research.
Papers
More filters
Journal ArticleDOI
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL
Kate E. Lawlor,Nufail Khan,Alison L Mildenhall,Motti Gerlic,Ben A. Croker,Akshay A. D’Cruz,Cathrine Hall,Sukhdeep Kaur. Spall,Holly Anderton,Seth L. Masters,Maryam Rashidi,Ian P. Wicks,Warren S. Alexander,Yasuhiro Mitsuuchi,Christopher A. Benetatos,Stephen M. Condon,W. Wei-Lynn Wong,John Silke,David L. Vaux,James E Vince +19 more
TL;DR: It is shown that following LPS treatment, or LPS-induced necroptosis, the TLR adaptor protein TRIF and inhibitor of apoptosis proteins (IAPs: X-linked IAP, cellular IAP1 and IAP2) regulate RIPK3 and MLKL ubiquitylation, and RIPK 3 can promote NLRP3 inflammasome and IL-1β inflammatory responses independent ofMLKL and necroPTotic cell death.
Journal ArticleDOI
Structure and function of the SPRY/B30.2 domain proteins involved in innate immunity
Akshay A. D’Cruz,Jeffrey J. Babon,Jeffrey J. Babon,Raymond S. Norton,Nicos A. Nicola,Nicos A. Nicola,Sandra E. Nicholson,Sandra E. Nicholson +7 more
TL;DR: The current structural and biochemical literature on SPRY/B30.2 domain involvement in key immune processes is examined and a PRY‐like 60 amino acid region in the N‐terminus of “SPRY‐only” proteins is highlighted.
Journal ArticleDOI
The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils
Akshay A. D’Cruz,Akshay A. D’Cruz,Mary Speir,Mary Speir,Meghan Bliss-Moreau,Meghan Bliss-Moreau,Sylvia Dietrich,Sylvia Dietrich,Shu Wang,Alyce A. Chen,Alyce A. Chen,Mathilde Gavillet,Mathilde Gavillet,Mathilde Gavillet,Arshed Al-Obeidi,Kate E. Lawlor,James E Vince,Michelle A. Kelliher,Razq Hakem,Manolis Pasparakis,David A. Williams,David A. Williams,Maria Ericsson,Ben A. Croker,Ben A. Croker +24 more
TL;DR: A distinct signaling network is defined that activates PAD4-dependent NET release for the control of methicillin-resistant Staphylococcus aureus (MRSA) infection and identifies necroptosis as a critical pathway that stimulates NETosis necessary for host defense.
Journal ArticleDOI
Crystal structure of the TRIM25 B30.2 (PRYSPRY) domain: a key component of antiviral signalling.
Akshay A. D’Cruz,Akshay A. D’Cruz,Nadia J. Kershaw,Nadia J. Kershaw,Jessica J. Chiang,May K. Wang,Nicos A. Nicola,Nicos A. Nicola,Jeffrey J. Babon,Jeffrey J. Babon,Michaela U. Gack,Sandra E. Nicholson,Sandra E. Nicholson +12 more
TL;DR: The present study describes the 1.8 Å crystal structure of the TRIM25 B30.2 domain, a protein-interaction domain composed of the PRY and SPRY tandem sequence motifs, and identifies a putative binding pocket, which is likely to be involved in binding target proteins.
Journal ArticleDOI
TLR Regulation of SPSB1 Controls Inducible Nitric Oxide Synthase Induction
Rowena S. Lewis,Tatiana B. Kolesnik,Zhihe Kuang,Akshay A. D’Cruz,Akshay A. D’Cruz,Marnie E. Blewitt,Seth L. Masters,Andrew Low,Tracy A. Willson,Raymond S. Norton,Sandra E. Nicholson,Sandra E. Nicholson +11 more
TL;DR: It is shown that SPSB1 controls both the induction of iNOS and the subsequent production of NO downstream of TLR3 and TLR4, and it is demonstrated that regulation ofiNOS by S PSB1 is dependent on the proteasome.