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Michaela U. Gack

Researcher at Cleveland Clinic

Publications -  95
Citations -  10370

Michaela U. Gack is an academic researcher from Cleveland Clinic. The author has contributed to research in topics: Innate immune system & RIG-I. The author has an hindex of 39, co-authored 78 publications receiving 7450 citations. Previous affiliations of Michaela U. Gack include University of Southern California & University of Illinois at Chicago.

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TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

Michaela U. Gack, +13 more
- 19 Apr 2007 - 
TL;DR: It is demonstrated that TRIM25 E3 ubiquitin ligase induces the Lys 63-linked ubiquitination of RIG-I, which is crucial for the cytosolic Rig-I signalling pathway to elicit host antiviral innate immunity.
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
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Influenza A Virus NS1 Targets the Ubiquitin Ligase TRIM25 to Evade Recognition by the Host Viral RNA Sensor RIG-I

Michaela U. Gack, +13 more
- 21 May 2009 - 
TL;DR: This work reports that the influenza A virus nonstructural protein 1 (NS1) specifically inhibits TRIM25-mediated RIG-I CARD ubiquitination, thereby suppressing Rig-I signal transduction and revealing a mechanism by which influenza virus inhibits host IFN response.
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Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking

Chengyu Liang, +15 more
- 15 Jun 2008 - 
TL;DR: It is reported that a Beclin1-binding autophagic tumour suppressor, UVRAG, interacts with the class C Vps complex, a key component of the endosomal fusion machinery, and this interaction stimulates Rab7 GTPase activity and autophagosome fusion with late endosomes/lysosomes, thereby enhancing delivery and degradation of Autophagic cargo.
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RIG-I-like receptors: their regulation and roles in RNA sensing

Jan Rehwinkel, +1 more
- 13 Mar 2020 - 
TL;DR: How members of the RLR family are regulated is explained and the importance of the RLRs in viral infection, autoimmunity and cancer is reflected on.