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Ben A. Croker
Researcher at University of California, San Diego
Publications - 81
Citations - 6656
Ben A. Croker is an academic researcher from University of California, San Diego. The author has contributed to research in topics: SOCS3 & Inflammation. The author has an hindex of 32, co-authored 75 publications receiving 5694 citations. Previous affiliations of Ben A. Croker include Royal Melbourne Hospital & University of Melbourne.
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Journal ArticleDOI
SOCS3 negatively regulates IL-6 signaling in vivo.
Ben A. Croker,Danielle L. Krebs,Jian-Guo Zhang,Sam Wormald,Tracy A. Willson,Edouard G. Stanley,Lorraine Robb,Christopher J. Greenhalgh,Irmgard Förster,Björn E. Clausen,Nicos A. Nicola,Donald Metcalf,Douglas J. Hilton,Andrew W. Roberts,Warren S. Alexander +14 more
TL;DR: It is shown that Socs3 deficiency results in prolonged activation of signal transducer and activator of transcription 1 (STAT1) and STAT3 after IL-6 stimulation but normal activation of STAT1 after stimulation with interferon-γ (IFN-γ).
Journal ArticleDOI
Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large
Bruce Beutler,Zhengfan Jiang,Philippe Georgel,Karine Crozat,Ben A. Croker,Sophie Rutschmann,Xin Du,Kasper Hoebe +7 more
TL;DR: The positional cloning of a spontaneous mutation that caused lipopolysaccharide resistance and susceptibility to Gram-negative infection led directly to the understanding that Toll-like receptors (TLRs) are essential sensors of microbial infection.
Journal ArticleDOI
SOCS regulation of the JAK/STAT signalling pathway
TL;DR: This review focuses on the mechanics of SOCS action and the complexities of the mouse models that have underpinned the current understanding of SOCs biology.
Journal ArticleDOI
RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.
James A Rickard,James A Rickard,Joanne A. O’Donnell,Joanne A. O’Donnell,Joseph M Evans,Joseph M Evans,Najoua Lalaoui,Najoua Lalaoui,Ashleigh R Poh,Ashleigh R Poh,TeWhiti Rogers,James E Vince,James E Vince,Kate E. Lawlor,Kate E. Lawlor,Robert L Ninnis,Robert L Ninnis,Holly Anderton,Holly Anderton,Cathrine Hall,Cathrine Hall,Sukhdeep K Spall,Sukhdeep K Spall,Toby J. Phesse,Toby J. Phesse,Helen E. Abud,Louise H. Cengia,Louise H. Cengia,Jason Corbin,Jason Corbin,Sandra Mifsud,Sandra Mifsud,Ladina Di Rago,Ladina Di Rago,Donald Metcalf,Donald Metcalf,Matthias Ernst,Matthias Ernst,Grant Dewson,Grant Dewson,Andrew W. Roberts,Andrew W. Roberts,Warren S. Alexander,Warren S. Alexander,James M. Murphy,James M. Murphy,Paul G Ekert,Paul G Ekert,Seth L. Masters,Seth L. Masters,David L. Vaux,David L. Vaux,Ben A. Croker,Ben A. Croker,Ben A. Croker,Motti Gerlic,Motti Gerlic,Motti Gerlic,John Silke,John Silke +59 more
TL;DR: A key function for RIPK1 is revealed in inhibiting necroptosis and, thereby, a role in limiting, not only promoting, inflammation is revealed.
Journal ArticleDOI
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL
Kate E. Lawlor,Nufail Khan,Alison L Mildenhall,Motti Gerlic,Ben A. Croker,Akshay A. D’Cruz,Cathrine Hall,Sukhdeep Kaur. Spall,Holly Anderton,Seth L. Masters,Maryam Rashidi,Ian P. Wicks,Warren S. Alexander,Yasuhiro Mitsuuchi,Christopher A. Benetatos,Stephen M. Condon,W. Wei-Lynn Wong,John Silke,David L. Vaux,James E Vince +19 more
TL;DR: It is shown that following LPS treatment, or LPS-induced necroptosis, the TLR adaptor protein TRIF and inhibitor of apoptosis proteins (IAPs: X-linked IAP, cellular IAP1 and IAP2) regulate RIPK3 and MLKL ubiquitylation, and RIPK 3 can promote NLRP3 inflammasome and IL-1β inflammatory responses independent ofMLKL and necroPTotic cell death.