Ghyslaine Martel-Planche

TL;DR: The predictive value of the test, the quantitative relationship between mutagenicity versus electrophilicity versus carcinogenicity of some selected carcinogens, and some factors involved in the efficient detection of mutagens in vitro were analyzed.

TL;DR: The results indicate that G4 structures in intron 3 regulate the splicing of intron 2, leading to differential expression of transcripts encoding distinct p53 isoforms, including Δ40p53, an isoform lacking first 39 N-terminal residues corresponding to the main transactivation domain.

TL;DR: In this article, the p53 mutations in cancers of factory workers with a history of carcinogen exposure in the workplace were found in exons 5-8 of the MDM2 gene.

TL;DR: Results show that the TP53 R337H germline mutation predisposes to a larger spectrum of tumours, similar to the one reported for other TP53 mutations.

TL;DR: Analysis of the patterns of 103 tumors diagnosed in 12 families showed that the presence of p.R337H is associated with multiple cancers of the Li‐Fraumeni Syndrome (LFS) spectrum, with relatively low penetrance before the age of 30 but a lifetime risk comparable to classical LFS.