A
Alain Jacquier
Researcher at Centre national de la recherche scientifique
Publications - 93
Citations - 11360
Alain Jacquier is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: RNA splicing & Gene. The author has an hindex of 51, co-authored 92 publications receiving 10793 citations. Previous affiliations of Alain Jacquier include Brandeis University & Spanish National Research Council.
Papers
More filters
Journal ArticleDOI
RNA degradation by the exosome is promoted by a nuclear polyadenylation complex
John LaCava,Jonathan Houseley,Cosmin Saveanu,Elisabeth Petfalski,Elizabeth Thompson,Alain Jacquier,David Tollervey +6 more
TL;DR: In vivo analyses showed that TRAMP is required for polyadenylation and degradation of rRNA and snoRNA precursors that are characterized exosome substrates, suggesting that this function was maintained in eukaryotic nuclei, while cytoplasmic mRNA poly(A) tails acquired different roles in translation.
Journal ArticleDOI
Cryptic Pol II Transcripts Are Degraded by a Nuclear Quality Control Pathway Involving a New Poly(A) Polymerase
Françoise Wyers,Mathieu Rougemaille,Gwenael Badis,Jean-Claude Rousselle,Marie-Elisabeth Dufour,Jocelyne Boulay,Béatrice Regnault,Frédéric Devaux,Abdelkader Namane,Bertrand Séraphin,Bertrand Séraphin,Domenico Libri,Alain Jacquier +12 more
TL;DR: It is shown here that several supposedly silent intergenic regions in the genome of S. cerevisiae are actually transcribed by RNA polymerase II, suggesting that the expressed fraction of the genome is higher than anticipated.
Journal ArticleDOI
Widespread bidirectional promoters are the major source of cryptic transcripts in yeast
Helen Neil,Christophe Malabat,Yves d'Aubenton-Carafa,Zhenyu Xu,Lars M. Steinmetz,Alain Jacquier +5 more
TL;DR: The first high-resolution genomic map of Cryptic unstable transcripts in yeast is reported, revealing a class of potentially functional CUTs and the intrinsic bidirectional nature of eukaryotic promoters.
Journal ArticleDOI
Human L1 element target-primed reverse transcription in vitro
TL;DR: The initial stages of L1 element transposition in vitro is reconstituted and evidence for specific positioning of the L1 RNA with the ORF2 protein is found, probably mediated in part by the polyadenosine portion of L 1 RNA.
Journal ArticleDOI
The complex eukaryotic transcriptome: unexpected pervasive transcription and novel small RNAs.
TL;DR: This Review focuses on small non-coding RNAs (ncRNAs) that have been found to be associated with promoters in eukaryotes from animals to yeast and discusses how the models proposed for their origins and their possible functions challenge previous views of the basic transcription process and its regulation.