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Alain L. Servin

Researcher at French Institute of Health and Medical Research

Publications -  120
Citations -  12170

Alain L. Servin is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Bacterial adhesin & Cellular differentiation. The author has an hindex of 51, co-authored 120 publications receiving 11538 citations. Previous affiliations of Alain L. Servin include Nestlé & University of Paris.

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Antagonistic activities of lactobacilli and bifidobacteria against microbial pathogens

TL;DR: There is increasing evidence that lactobacilli and bifidobacteria, which inhabit the gastrointestinal microbiota, develop antimicrobial activities that participate in the host's gastrointestinal system of defence.
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Lactobacillus acidophilus LA 1 binds to cultured human intestinal cell lines and inhibits cell attachment and cell invasion by enterovirulent bacteria.

TL;DR: Investigation of the inhibitory effect of LA 1 organisms against Caco-2 cell adhesion and cell invasion by a large variety of diarrhoeagenic bacteria found incubation before and together with enterovirulent E coli were more effective than incubation after infection by E coli.
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The Front Line of Enteric Host Defense against Unwelcome Intrusion of Harmful Microorganisms: Mucins, Antimicrobial Peptides, and Microbiota

TL;DR: Whether the cells producing mucins or antimicrobial peptides and the resident microbiota act in partnership and whether they function individually and/or synergistically to provide the host with an effective front line of defense against harmful enteric pathogens is examined.
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Immune modulation of blood leukocytes in humans by lactic acid bacteria: criteria for strain selection.

TL;DR: Bacterial adhesion to enterocytes, fecal colonization, or both seem to be valuable selection criteria for immunomodulation, and antiinfective mechanisms of defense can be enhanced after ingestion of specific lactic acid bacteria strains.
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Bifidobacterium strains from resident infant human gastrointestinal microflora exert antimicrobial activity

TL;DR: Several bifidobacterium strains from resident infant human gastrointestinalmicroflora exert antimicrobial activity, suggesting that they could participate in the “barrier effect” produced by the indigenous microflora.