https://www.commed.vcu.edu/Chronic_Disease/2012/cochranrvwrschbias.pdf

The Cochrane Collaboration's tool for assessing risk of bias in randomised trials

[Crohn's disease].

Epidemiology and Natural History of Inflammatory Bowel Diseases

https://www.thelancet.com/pdfs/journals/lancet/PIIS0140673612600269.pdf

Crohn's disease

Eosinophilic esophagitis (EoE) is a clinicopathologic condition of increasing recognition and prevalence. In 2007, a consensus recommendation provided clinical and histopathologic guidance for the diagnosis and treatment of EoE; however, only a minority of physicians use the 2007 guidelines, which require fulfillment of both histologic and clinical features. Since 2007, the number of EoE publications has doubled, providing new disease insight. Accordingly, a panel of 33 physicians with expertise in pediatric and adult allergy/immunology, gastroenterology, and pathology conducted a systematic review of the EoE literature (since September 2006) using electronic databases. Based on the literature review and expertise of the panel, information and recommendations were provided in each of the following areas of EoE: diagnostics, genetics, allergy testing, therapeutics, and disease complications. Because accumulating animal and human data have provided evidence that EoE appears to be an antigen-driven immunologic process that involves multiple pathogenic pathways, a new conceptual definition is proposed highlighting that EoE represents a chronic, immune/antigen-mediated disease characterized clinically by symptoms related to esophageal dysfunction and histologically by eosinophil-predominant inflammation. The diagnostic guidelines continue to define EoE as an isolated chronic disorder of the esophagus diagnosed by the need of both clinical and pathologic features. Patients commonly have high rates of concurrent allergic diatheses, especially food sensitization, compared with the general population. Proved therapeutic options include chronic dietary elimination, topical corticosteroids, and esophageal dilation. Important additions since 2007 include genetic underpinnings that implicate EoE susceptibility caused by polymorphisms in the thymic stromal lymphopoietin protein gene and the description of a new potential disease phenotype, proton pump inhibitor-responsive esophageal eosinophila. Further advances and controversies regarding diagnostic methods, surrogate disease markers, allergy testing, and treatment approaches are discussed.

/pdf/eosinophilic-esophagitis-updated-consensus-recommendations-16knxh59cv.pdf

Eosinophilic esophagitis: Updated consensus recommendations for children and adults

S1855 Monotherapy of Stenosing Eosinophilic Esophagitis with Dilation: the Patient's View of Efficacy and Tolerability

https://www.zora.uzh.ch/id/eprint/178515/1/CGH_revised_EoE_and_Pregnancy_without_changes_marked_ZORA.pdf

Disease Progression and Outcomes of Pregnancies in Women With Eosinophilic Esophagitis

AIM To assess different techniques to measure body composition in paediatric patients with inflammatory bowel disease using dual energy X-ray absorptiometry as a reference method. We hypothesised that a three-compartment model may demonstrate superiority over other methods as skinfold thickness equations and bioelectrical impedance analysis. METHODS Body composition was assessed using skinfold thickness equations, bioelectrical impedance analysis and the three-compartment model. Data obtained with these methods were compared to the results obtained by dual energy X-ray absorptiometry. Statistical analysis was performed using Spearman's correlation and Bland-Altman's limits of agreement method. RESULTS Twenty-one paediatric patients with inflammatory bowel disease were included: 11 females and 10 males; mean age for the entire group: 14.3 years, range 12-16 years. In children with inflammatory bowel disease, skinfold thickness equations, bioelectrical impedance analysis and the three-compartment model showed reliable measurements with small differences in the percentage of total body fat and good limits of agreements. CONCLUSION The assessment of body composition using bioelectrical impedance analysis provides a valid and accurate method in children with inflammatory bowel disease as compared to dual energy X-ray absorptiometry. In the future, superiority of 3-compartment model in research and clinical settings of nutritional intervention and disease status in children with inflammatory bowel disease remains to be demonstrated.

Body composition assessment in children with inflammatory bowel disease: A comparison of different methods.

S1193 Phenotypic Associations of Crohn's Disease with Antibodies to Flagellins A4-Fla2, Fla-X, ASCA, pANCA and CARD15 Mutations in a Swiss Cohort

http://academic.oup.com/ecco-jcc/article-pdf/12/supplement_1/S328/23744479/jjx180.570.pdf

Alain M. Schoepfer

Papers

S1855 Monotherapy of Stenosing Eosinophilic Esophagitis with Dilation: the Patient's View of Efficacy and Tolerability

Disease Progression and Outcomes of Pregnancies in Women With Eosinophilic Esophagitis

Body composition assessment in children with inflammatory bowel disease: A comparison of different methods.

S1193 Phenotypic Associations of Crohn's Disease with Antibodies to Flagellins A4-Fla2, Fla-X, ASCA, pANCA and CARD15 Mutations in a Swiss Cohort

P443 Systematic analysis of annual health resource utilisation and costs in hospitalised inflammatory bowel disease patients in Switzerland