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Alain M. Schoepfer
Researcher at University Hospital of Lausanne
Publications - 321
Citations - 16599
Alain M. Schoepfer is an academic researcher from University Hospital of Lausanne. The author has contributed to research in topics: Eosinophilic esophagitis & Medicine. The author has an hindex of 51, co-authored 265 publications receiving 13251 citations. Previous affiliations of Alain M. Schoepfer include University of Zurich & McMaster University.
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Journal ArticleDOI
Concept for a rapid point-of-care calprotectin diagnostic test for diagnosis and disease activity monitoring in patients with inflammatory bowel disease: expert clinical opinion
Gerhard Rogler,Xavier Aldeguer,Wolfgang Kruis,Anders Lasson,Ulrich Mittmann,Kenneth Nally,Laurent Peyrin-Biroulet,Alain M. Schoepfer,Morten H. Vatn,Stephan R. Vavricka,Robert Logan +10 more
TL;DR: In this article, the authors describe Crohn's disease, diagnosis tests, Inflammatory bowel disease, Irritable bowel syndrome, Ulcerative colitis, and other symptoms.
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The gap between scientific evidence and clinical practice: 5-aminosalicylates are frequently used for the treatment of Crohn's disease.
Alain M. Schoepfer,Murielle Bortolotti,Valérie Pittet,Christian Mottet,Christian Mottet,J.-J. Gonvers,O. Reich,Nicolas Fournier,John Paul Vader,Bernard Burnand,Pierre Michetti,Florian Froehlich,Florian Froehlich +12 more
TL;DR: There is uncertain evidence of effectiveness of 5‐aminosalicylates (5‐ASA) to induce and maintain response and remission of active Crohn's disease (CD), and weak evidence to support their use in post‐operative CD.
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Anti-Saccharomyces cerevisiae mannan antibodies (ASCA) of Crohn's patients crossreact with mannan from other yeast strains, and murine ASCA IgM can be experimentally induced with Candida albicans.
Thomas Schaffer,Stefan Müller,Beatrice Flogerzi,Beatrice Seibold-Schmid,Alain M. Schoepfer,Frank Seibold +5 more
TL;DR: The inability of mice to readily generate ASCA is in line with the current opinion that genetic predisposition is a prerequisite for the development of this and other unusual immune reactivities in CD.
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A new eosinophilic esophagitis (EoE)-like disease without tissue eosinophilia found in EoE families.
A. Straumann,Carine Blanchard,Susanne Radonjic-Hoesli,Ch Bussmann,Petr Hruz,Ekaterina Safroneeva,Dagmar Simon,Alain M. Schoepfer,Hans-Uwe Simon +8 more
TL;DR: Patients presenting with EoE‐typical and corticosteroid‐responsive symptoms, but without tissue eosinophilia are identified, to clinically and immunologically characterize these patients with EOE‐like disease.
Journal ArticleDOI
Long-term Efficacy and Tolerability of RPC4046 in an Open-Label Extension Trial of Patients With Eosinophilic Esophagitis
Evan S. Dellon,Margaret H. Collins,Marc E. Rothenberg,Yehudith Assouline-Dayan,Larry Evans,Sandeep K. Gupta,Alain M. Schoepfer,Alex Straumann,Ekaterina Safroneeva,Cristian Rodriguez,Neil Minton,Steven Y. Hua,Ikuo Hirano +12 more
TL;DR: One year treatment with RPC4046 is generally well tolerated and results in continued improvement and/or maintenance of endoscopic, histologic, and clinical measures of EoE disease activity relative to baseline.