D
Dorit B. Donoviel
Researcher at Baylor College of Medicine
Publications - 39
Citations - 3512
Dorit B. Donoviel is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Presenilin & Notch signaling pathway. The author has an hindex of 22, co-authored 37 publications receiving 3298 citations. Previous affiliations of Dorit B. Donoviel include Mount Sinai Hospital & Translational Research Institute.
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Journal ArticleDOI
Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells.
Seiji Hitoshi,Tania O. Alexson,Vincent Tropepe,Dorit B. Donoviel,Andrew J. Elia,Jeffrey S. Nye,Ronald A. Conlon,Tak W. Mak,Alan Bernstein,Derek van der Kooy +9 more
TL;DR: Both neuronal and glial differentiation in vitro were enhanced by attenuation of Notch signaling and suppressed by expressing an active form of NotCh1, consistent with a role for NotCh signaling in the maintenance of the neural stem cell, and inconsistent with a roles in a neuronal/glial fate switch.
Journal ArticleDOI
Mice lacking both presenilin genes exhibit early embryonic patterning defects.
Dorit B. Donoviel,Anna-Katerina Hadjantonakis,Masaki Ikeda,Hui Zheng,Peter St. George Hyslop,Alan Bernstein +5 more
TL;DR: It is concluded that the presenilins play a widespread role in embryogenesis, that there is a functional redundancy between PS1 and PS2, and that both vertebrate presenILins, like their invertebrate homologs, are essential for Notch signaling.
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Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN.
Dorit B. Donoviel,Deon D. Freed,Hannes Vogel,David Potter,Edith P. Hawkins,James Barrish,Brian N. Mathur,C. Alexander Turner,Robert S. Geske,Charles A. Montgomery,Michael Starbuck,Mary L. Brandt,Anupma Gupta,Ramiro Ramirez-Solis,Brian Zambrowicz,David R. Powell +15 more
TL;DR: Findings suggest that NEPH1, like NEPHRIN, may play an important role in maintaining the structure of the filtration barrier that prevents proteins from freely entering the glomerular urinary space.
Journal ArticleDOI
Presenilins are required for γ -secretase cleavage of β -APP and transmembrane cleavage of Notch-1
Zhuohua Zhang,Philip Nadeau,Weihong Song,Dorit B. Donoviel,Menglan Yuan,Alan Bernstein,Bruce A. Yankner +6 more
TL;DR: Presenilins are required for γ -secretase cleavage of β -APP and transmembrane cleaving of Notch-1 and trans Membrane Cleavage of NotCh-1.
Journal Article
mdmx Is a Negative Regulator of p53 Activity in Vivo
Rick Avery Finch,Dorit B. Donoviel,David Potter,Min Shi,Amy Fan,Deon D. Freed,Ching Yun Wang,Brian Zambrowicz,Ramiro Ramirez-Solis,Arthur T. Sands,Nan Zhang +10 more
TL;DR: It is reported that loss of mdmx, a p53-binding protein, results in midgestational embryo lethality, a phenotype that is completely rescued by the absence of p53.