E
Erdem Sendinc
Researcher at Boston Children's Hospital
Publications - 12
Citations - 964
Erdem Sendinc is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Messenger RNA & RNA. The author has an hindex of 6, co-authored 9 publications receiving 583 citations. Previous affiliations of Erdem Sendinc include University of Virginia Health System & Harvard University.
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Journal ArticleDOI
DNA Methylation on N6-Adenine in C. elegans
Eric L. Greer,Eric L. Greer,Mario Andres Blanco,Mario Andres Blanco,Lei Gu,Lei Gu,Erdem Sendinc,Erdem Sendinc,Jianzhao Liu,David Aristizábal-Corrales,David Aristizábal-Corrales,Chih-Hung Hsu,Chih-Hung Hsu,L. Aravind,Chuan He,Yang Shi,Yang Shi +16 more
TL;DR: The presence of adenine N(6)-methylation (6mA) in C. elegans DNA is demonstrated and the exciting possibility that 6mA may be a carrier of heritable epigenetic information in eukaryotes is raised.
Journal ArticleDOI
PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression.
Erdem Sendinc,David Valle-Garcia,David Valle-Garcia,Abhinav Dhall,Abhinav Dhall,Hao Chen,Hao Chen,Telmo Henriques,José Navarrete-Perea,Wanqiang Sheng,Wanqiang Sheng,Steven P. Gygi,Karen Adelman,Yang Shi,Yang Shi +14 more
TL;DR: It is demonstrated that m6Am is an evolutionarily conserved mRNA modification mediated by the Phosphorylated CTD Interacting Factor 1 (PCIF1), which catalyzes m6A methylation on 2-O-methylated adenine located at the 5' ends of mRNAs.
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METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation.
Esteban A. Orellana,Esteban A. Orellana,Qi Liu,Qi Liu,Eliza Yankova,Eliza Yankova,Mehdi Pirouz,Mehdi Pirouz,Etienne De Braekeleer,Wen Cai Zhang,Jihoon Lim,Demetrios Aspris,Erdem Sendinc,Dimitrios A. Garyfallos,Dimitrios A. Garyfallos,Muxin Gu,Raja Hussain Ali,Alejandro Gutierrez,Alejandro Gutierrez,Sigitas Mikutis,Gonçalo J. L. Bernardes,Eric S. Fischer,Allan Bradley,George S. Vassiliou,George S. Vassiliou,Frank J. Slack,Frank J. Slack,Konstantinos Tzelepis,Konstantinos Tzelepis,Richard I. Gregory +29 more
TL;DR: In this article, the RNA methyltransferase METTL1 catalyzes N7-methylguanosine (m7G) modification of tRNAs and is associated with poor patient survival.
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Nucleotide resolution profiling of m3C RNA modification by HAC-seq.
TL;DR: HAC-seq provides a novel method for the unbiased, transcriptome-wide identification of 3-Methylcytidine (m3C) RNA modification at single-nucleotide resolution, and could be widely applied to reveal the m3C methylome in different cells and tissues.
Journal ArticleDOI
meCLICK-Seq, a Substrate-Hijacking and RNA Degradation Strategy for the Study of RNA Methylation.
Sigitas Mikutis,Muxin Gu,Erdem Sendinc,Madoka E Hazemi,Hannah Kiely-Collins,Demetrios Aspris,George S. Vassiliou,George S. Vassiliou,Yang Shi,Yang Shi,Konstantinos Tzelepis,Konstantinos Tzelepis,Konstantinos Tzelepis,Gonçalo J. L. Bernardes,Gonçalo J. L. Bernardes +14 more
TL;DR: MeCLICK-Seq as discussed by the authors uses click-degraders, small molecules that can be covalently attached to RNA species through click-chemistry and can degrade them, that are akin to ribonucleases.