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Alan M. Krensky
Researcher at National Institutes of Health
Publications - 286
Citations - 19229
Alan M. Krensky is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Cytotoxic T cell & Granulysin. The author has an hindex of 75, co-authored 286 publications receiving 18552 citations. Previous affiliations of Alan M. Krensky include Stanford University & Harvard University.
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Journal ArticleDOI
An Antimicrobial Activity of Cytolytic T Cells Mediated by Granulysin
Steffen Stenger,Dennis A. Hanson,Rachel Teitelbaum,Puneet Dewan,Kayvan Niazi,Christopher J. Froelich,Tomas Ganz,Sybille Thoma-Uszynski,Agustı́n Melián,Christian Bogdan,Steven A. Porcelli,Barry R. Bloom,Alan M. Krensky,Robert L. Modlin +13 more
TL;DR: The ability of CTLs to kill intracellular M. tuberculosis was dependent on the presence of granulysin in cytotoxic granules, defining a mechanism by which T cells directly contribute to immunity against intrACEllular pathogens.
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Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3.
Francisco Sánchez-Madrid,Alan M. Krensky,Carl F. Ware,Elizabeth Robbins,Jack L. Strominger,Steven J. Burakoff,Timothy A. Springer +6 more
TL;DR: Monoclonal antibodies were prepared to anti-HLA-DR cytolytic T lymphocytes (CTLs) and screened for inhibition of CTL-mediated killing, suggesting that these molecules participate in the C TL-target cell interaction.
Journal Article
The functional significance, distribution, and structure of LFA-1, LFA-2, and LFA-3: cell surface antigens associated with CTL-target interactions.
Alan M. Krensky,Francisco Sánchez-Madrid,Elizabeth Robbins,Janice A. Nagy,Timothy A. Springer,Steven J. Burakoff +5 more
TL;DR: Three cell surface antigens associated with the cy tolytic T lymphocyte(CTL)-target cell interaction were identified by generation of monoclonal antibodies (MAb) against OKT4+, HLA-DR-specific CTL and selection for inhibition of cytolysis in a 51Cr-release assay to demonstrate the complexity of CTL-mediated cytotoxicity at the molecular level.
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A binding site for the T-cell co-receptor CD8 on the alpha 3 domain of HLA-A2.
Russell D. Salter,Richard J. Benjamin,Pamela K. Wesley,Sarah E. Buxton,Thomas P. J. Garrett,Carol Clayberger,Alan M. Krensky,Anne M. Norment,Dan R. Littman,Peter Parham +9 more
TL;DR: Adhesion measurements between CD8 and 48 point mutants of HLA-A2.1 have shown that the CD8 alpha-chain binds to the alpha 3 domain of the protein-protein interaction as mentioned in this paper.
Journal Article
A human T cell-specific molecule is a member of a new gene family.
Thomas J. Schall,Jan Jongstra,Bradley J. Dyer,Jeffrey L. Jorgensen,Carol Clayberger,Mark M. Davis,Alan M. Krensky +6 more
TL;DR: There is significant homology between the RANTES sequence and several other T cell genes, suggesting that they comprise a previously undescribed family of small T cell molecules.