C
Christian Bogdan
Researcher at University of Erlangen-Nuremberg
Publications - 280
Citations - 26903
Christian Bogdan is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Immune system & Leishmania major. The author has an hindex of 70, co-authored 262 publications receiving 24367 citations. Previous affiliations of Christian Bogdan include Robert Koch Institute & University of Freiburg.
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Nitric oxide and the immune response
TL;DR: Its striking inter- and intracellular signaling capacity makes it extremely difficult to predict the effect of NOS inhibitors and NO donors, which still hampers therapeutic applications.
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Macrophage deactivation by interleukin 10.
TL;DR: In this article, the authors showed that the IL-10 was exceedingly potent at suppressing the ability of mouse peritoneal macrophages (m phi) to release tumor necrosis factor alpha (TNF-alpha).
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An Antimicrobial Activity of Cytolytic T Cells Mediated by Granulysin
Steffen Stenger,Dennis A. Hanson,Rachel Teitelbaum,Puneet Dewan,Kayvan Niazi,Christopher J. Froelich,Tomas Ganz,Sybille Thoma-Uszynski,Agustı́n Melián,Christian Bogdan,Steven A. Porcelli,Barry R. Bloom,Alan M. Krensky,Robert L. Modlin +13 more
TL;DR: The ability of CTLs to kill intracellular M. tuberculosis was dependent on the presence of granulysin in cytotoxic granules, defining a mechanism by which T cells directly contribute to immunity against intrACEllular pathogens.
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LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.
Almut Brand,Katrin Singer,Gudrun E. Koehl,Marlene Kolitzus,Gabriele Schoenhammer,Annette Thiel,Carina Matos,Christina Bruss,Sebastian Klobuch,K. Peter,K. Peter,Michael Kastenberger,Christian Bogdan,Ulrike Schleicher,Andreas Mackensen,Evelyn Ullrich,Stefan Fichtner-Feigl,Stefan Fichtner-Feigl,Rebecca Kesselring,Matthias Mack,Matthias Mack,Uwe Ritter,Maximilian Schmid,Maximilian Schmid,Christian U. Blank,Katja Dettmer,Peter J. Oefner,Petra Hoffmann,Petra Hoffmann,Stefan Walenta,E. K. Geissler,Jacques Pouysségur,Andreas Villunger,André Steven,Barbara Seliger,Stephan Schreml,Sebastian Haferkamp,Elisabeth Kohl,Sigrid Karrer,Mark Berneburg,Wolfgang Herr,Wolfgang Mueller-Klieser,Kathrin Renner,Kathrin Renner,Marina Kreutz,Marina Kreutz +45 more
TL;DR: It is shown that LDHA-associated lactic acid accumulation in melanomas inhibits tumor surveillance by T and NK cells, and is a potent inhibitor of function and survival of T andNK cells leading to tumor immune escape.
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Reactive oxygen and reactive nitrogen intermediates in innate and specific immunity
TL;DR: Recent evidence for additional functions of these oxygen metabolites in innate and adaptive immunity include the modulation of the cytokine response of lymphocytes and the regulation of immune cell apoptosis, as well as immunodeviating effects.