R
Rachel Teitelbaum
Researcher at Albert Einstein College of Medicine
Publications - 6
Citations - 1950
Rachel Teitelbaum is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Mycobacterium tuberculosis & Cytotoxic T cell. The author has an hindex of 6, co-authored 6 publications receiving 1881 citations. Previous affiliations of Rachel Teitelbaum include Howard Hughes Medical Institute & Harvard University.
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Journal ArticleDOI
An Antimicrobial Activity of Cytolytic T Cells Mediated by Granulysin
Steffen Stenger,Dennis A. Hanson,Rachel Teitelbaum,Puneet Dewan,Kayvan Niazi,Christopher J. Froelich,Tomas Ganz,Sybille Thoma-Uszynski,Agustı́n Melián,Christian Bogdan,Steven A. Porcelli,Barry R. Bloom,Alan M. Krensky,Robert L. Modlin +13 more
TL;DR: The ability of CTLs to kill intracellular M. tuberculosis was dependent on the presence of granulysin in cytotoxic granules, defining a mechanism by which T cells directly contribute to immunity against intrACEllular pathogens.
Journal ArticleDOI
A mAb recognizing a surface antigen of Mycobacterium tuberculosis enhances host survival.
Rachel Teitelbaum,Aharona Glatman-Freedman,Bing Chen,John B. Robbins,Emil R. Unanue,Arturo Casadevall,Barry R. Bloom,Barry R. Bloom +7 more
TL;DR: Mice treated with mAb 9d8 and challenged with M. tuberculosis localized the pathogen within granuloma centers, suggesting that the mAb conferred protection by enhancing a cellular immune response.
Journal ArticleDOI
Granulysin, a T Cell Product, Kills Bacteria by Altering Membrane Permeability
William A. Ernst,Sybille Thoma-Uszynski,Rachel Teitelbaum,Christine J. Ko,Dennis A. Hanson,Carol Clayberger,Alan M. Krensky,Matthias Leippe,Barry R. Bloom,Tomas Ganz,Robert L. Modlin +10 more
TL;DR: The data suggest that the ability of granulysin to kill microbial pathogens is dependent on direct interaction with the microbial cell wall and/or membrane, leading to increased permeability and lysis.
Journal ArticleDOI
Auxotrophic vaccines for tuberculosis.
Indira Guleria,Rachel Teitelbaum,Ruth Mcadam,Ganjam V. Kalpana,William R. Jacobs,Barry R. Bloom +5 more
TL;DR: Five auxotrophic strains of BCG produced by insertional mutagenesis are studied for safety in administration to mice with severe combined immunodeficiency disease (SCID), and for protection in a susceptible strain of mice to suggest that auxotrophs represent a potentially safe and useful vaccine against tuberculosis for populations at risk for HIV.
Journal ArticleDOI
Effects of protein calorie malnutrition on tuberculosis in mice.
John Chan,Yu Tian,Kathryn E. Tanaka,Ming S. Tsang,Keming Yu,Padmini Salgame,Padmini Salgame,Dinah Carroll,Yvonne Kress,Rachel Teitelbaum,Barry R. Bloom +10 more
TL;DR: The results indicate that protein calorie malnutrition selectively compromises several components of the cellular immune response that are important for containing and restricting tuberculous infection, and suggest that malnutrition-induced susceptibility to some infectious diseases can be reversed or ameliorated by nutritional intervention.