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Alan Moreira de Araujo
Researcher at University of Florida
Publications - 15
Citations - 376
Alan Moreira de Araujo is an academic researcher from University of Florida. The author has contributed to research in topics: Liver injury & Immune system. The author has an hindex of 9, co-authored 13 publications receiving 240 citations. Previous affiliations of Alan Moreira de Araujo include Universidade Federal de Minas Gerais & Yale University.
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Journal ArticleDOI
Combination of Mass Cytometry and Imaging Analysis Reveals Origin, Location, and Functional Repopulation of Liver Myeloid Cells in Mice
Bruna Araújo David,Rafael M. Rezende,Maísa Mota Antunes,Mônica Morais Santos,Maria Alice Freitas Lopes,Ariane Barros Diniz,Rafaela Vaz Sousa Pereira,Sarah Cozzer Marchesi,Débora Moreira Alvarenga,Brenda Naemi Nakagaki,Alan Moreira de Araujo,Daniela Reis,Renata Monti Rocha,Pedro Marques,Woo-Yong Lee,Justin F. Deniset,Pei Xiong Liew,Stephen Rubino,Laura M. Cox,Vanessa Pinho,Thiago M. Cunha,Gabriel Fernandes,André G. Oliveira,Mauro M. Teixeira,Paul Kubes,Gustavo B. Menezes +25 more
TL;DR: In studies of hepatic phagocyte depletion in mice, it is found that myeloid precursors can differentiate into liver macrophages and dendritic cells, which each localize to distinct tissue compartments.
Journal ArticleDOI
Immune and metabolic shifts during neonatal development reprogram liver identity and function.
Brenda Naemi Nakagaki,Kassiana Mafra,Érika de Carvalho,Mateus Eustáquio Lopes,Raquel Carvalho-Gontijo,Hortência Maciel de Castro-Oliveira,Gabriel Henrique Campolina-Silva,Camila Dutra Moreira de Miranda,Maísa Mota Antunes,Ana Carolina Carvalho Silva,Ariane Barros Diniz,Débora Moreira Alvarenga,Maria Alice Freitas Lopes,Viviane Aparecida de Souza Lacerda,Matheus Silvério Mattos,Alan Moreira de Araujo,Paula Vieira Teixeira Vidigal,Cristiano Xavier Lima,Germán A.B. Mahecha,Mila Fernandes Moreira Madeira,Gabriel Fernandes,Raquel Ferraz Nogueira,Thais Garcias Moreira,Bruna Araújo David,Rafael M. Rezende,Gustavo B. Menezes +25 more
TL;DR: In newborns, the immune and metabolic profiles of the liver are dramatically different to those of the adult liver, which can be explained by the differences in the liver cell repertoire and phenotype.
Journal ArticleDOI
Oxidative Stress Markers Correlate with Renal Dysfunction and Thrombocytopenia in Severe Leptospirosis
Alan Moreira de Araujo,Eliana A. G. Reis,Daniel Abensur Athanazio,Guilherme S. Ribeiro,José E. Hagan,Guilherme C. Araújo,Alcineia O. Damião,Nicolli S. Couto,Albert I. Ko,Alberto Noronha-Dutra,Mitermayer G. Reis +10 more
TL;DR: It was found that ROS production was higher and GSH levels were lower in leptospirosis patients compared with healthy individuals and among patients, GSH depletion was correlated with thrombocytopenia and elevated serum creatinine, whereas a strong positive correlation was observed between ROS production and elevated plasma potassium.
Journal ArticleDOI
Liver Immune Cells Release Type 1 Interferon Due to DNA Sensing and Amplify Liver Injury from Acetaminophen Overdose.
Alan Moreira de Araujo,Maísa Mota Antunes,Matheus Silvério Mattos,Ariane Barros Diniz,Débora Moreira Alvarenga,Brenda Naemi Nakagaki,Érika de Carvalho,Viviane Aparecida de Souza Lacerda,Raquel Carvalho-Gontijo,Jorge Goulart,Kassiana Mafra,Maria Alice Freitas-Lopes,Hortência Maciel de Castro Oliveira,Camila Miranda Dutra,Bruna Araújo David,Aristóbolo M. Silva,Valérie F. J. Quesniaux,Bernhard Ryffel,Sergio C. Oliveira,Glen N. Barber,Daniel S. Mansur,Thiago M. Cunha,Rafael M. Rezende,André G. Oliveira,Gustavo B. Menezes +24 more
TL;DR: A novel loop involving DNA recognition by hepatic NPCs and additional IFN-1 mediated hepatocyte death is demonstrated, which delayed APAP-mediated liver necrosis and dampened IFn-1 sensing pathways.
Journal ArticleDOI
IL-33 signalling in liver immune cells enhances drug-induced liver injury and inflammation
Maísa Mota Antunes,Alan Moreira de Araujo,Ariane Barros Diniz,Rafaela Vaz Sousa Pereira,Débora Moreira Alvarenga,Bruna Araújo David,Renata Monti Rocha,Maria Alice Freitas Lopes,Sarah Cozzer Marchesi,Brenda Naemi Nakagaki,Érika de Carvalho,Pedro Marques,Bernhard Ryffel,Valérie F. J. Quesniaux,Rodrigo Guabiraba Brito,José Carlos Farias Alves Filho,Denise Carmona Cara,Rafael M. Rezende,Gustavo B. Menezes +18 more
TL;DR: Blockage of IL-33/ST2 axis reduces APAP-mediated organ injury by dampening liver chemokine release and activation of resident and infiltrating liver non-parenchymal cells.