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Alan P. Wolffe
Researcher at Sangamo BioSciences
Publications - 237
Citations - 33119
Alan P. Wolffe is an academic researcher from Sangamo BioSciences. The author has contributed to research in topics: Chromatin & Nucleosome. The author has an hindex of 91, co-authored 237 publications receiving 32406 citations. Previous affiliations of Alan P. Wolffe include National Institutes of Health.
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Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription.
Peter L. Jones,Gert C. Jan Veenstra,Paul A. Wade,Danielle Vermaak,Stefan U. Kass,Nicoletta Landsberger,John Strouboulis,Alan P. Wolffe +7 more
TL;DR: The results establish a direct causal relationship between DNA methylation-dependent transcriptional silencing and the modification of chromatin.
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Methylation-induced repression--belts, braces, and chromatin.
Adrian Bird,Alan P. Wolffe +1 more
TL;DR: Although the signals that cause susceptibility or resistance to methylation are still unknown, genetic approaches in plants are leading the way forward and exciting revelations are expected as the knowledge vacuum in this area is filled over the next few years.
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Epigenetics: Regulation Through Repression
Alan P. Wolffe,Marjori Matzke +1 more
TL;DR: Epigenetics is the study of heritable changes in gene expression that occur without a change in DNA sequence, which can complicate the genetic manipulation of plants and animals.
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A positive role for histone acetylation in transcription factor access to nucleosomal DNA
TL;DR: It is suggested that the hist one tails have a major role in restricting transcription factor access to DNA and that their acetylation releases this restriction by directing dissociation of the tails from DNA and/or inducing a change in DNA configuration on the histone core to allow transcription factor binding.
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DNA methylation in health and disease
TL;DR: DNA methylation has recently moved to centre stage in the aetiology of human neurodevelopmental syndromes such as the fragile X, ICF and Rett Syndromes, and understanding this link will be central to the design of new therapeutic tools.