N
Nicoletta Landsberger
Researcher at University of Milan
Publications - 72
Citations - 6537
Nicoletta Landsberger is an academic researcher from University of Milan. The author has contributed to research in topics: MECP2 & Rett syndrome. The author has an hindex of 28, co-authored 67 publications receiving 6023 citations. Previous affiliations of Nicoletta Landsberger include National Institutes of Health & University of Insubria.
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Journal ArticleDOI
Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription.
Peter L. Jones,Gert C. Jan Veenstra,Paul A. Wade,Danielle Vermaak,Stefan U. Kass,Nicoletta Landsberger,John Strouboulis,Alan P. Wolffe +7 more
TL;DR: The results establish a direct causal relationship between DNA methylation-dependent transcriptional silencing and the modification of chromatin.
Journal ArticleDOI
DNA methylation directs a time-dependent repression of transcription initiation.
TL;DR: The mechanism of methylation-dependent HSV tk gene regulation is examined by direct determination of nucleoprotein organization during the establishment of a transcriptionally silenced state after microinjection of templates with defined methylation states into Xenopus oocyte nuclei.
Journal ArticleDOI
CDKL5 belongs to the same molecular pathway of MeCP2 and it is responsible for the early-onset seizure variant of Rett syndrome
Francesca Mari,Sara Azimonti,Ilaria Bertani,Fabrizio Bolognese,Elena Colombo,Rossella Caselli,Elisa Scala,Ilaria Longo,Salvatore Grosso,Chiara Pescucci,Francesca Ariani,Giuseppe Hayek,Paolo Balestri,Anna Bergo,Gianfranco Badaracco,Michele Zappella,Vania Broccoli,Alessandra Renieri,Charlotte Kilstrup-Nielsen,Nicoletta Landsberger +19 more
TL;DR: It is shown here that CDKL5 is a nuclear protein whose expression in the nervous system overlaps with that of MeCP2, during neural maturation and synaptogenesis, and that it is indeed a kinase, which is able to phosphorylate itself and to mediate Me CP2 phosphorylation, suggesting that they belong to the same molecular pathway.
Journal ArticleDOI
Molecular Mechanisms of Gene Silencing Mediated by DNA Methylation
TL;DR: It is demonstrated that a few methylated cytosines can inhibit a flanking promoter but a threshold of modified sites is required to organize a stable, diffusible chromatin structure.
Journal ArticleDOI
Oligomerization of RAR and AML1 Transcription Factors as a Novel Mechanism of Oncogenic Activation
Saverio Minucci,Marco Maccarana,Mario Cioce,Pasquale De Luca,Vania Gelmetti,Simona Segalla,Luciano Di Croce,Sabrina Giavara,Cristian Matteucci,Alberto Gobbi,Andrea Bianchini,Emanuela Colombo,Ilaria Schiavoni,Ilaria Schiavoni,Gianfranco Badaracco,Xiao Hu,Mitchell A. Lazar,Nicoletta Landsberger,Clara Nervi,Pier Giuseppe Pelicci +19 more
TL;DR: The results show that oligomerization of a transcription factor, imposing an altered interaction with transcriptional coregulators, represents a novel mechanism of oncogenic activation.