A
Alaric W. D’Souza
Researcher at Washington University in St. Louis
Publications - 18
Citations - 1043
Alaric W. D’Souza is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Antibiotic resistance & Microbiome. The author has an hindex of 9, co-authored 16 publications receiving 596 citations. Previous affiliations of Alaric W. D’Souza include Wayne State University.
Papers
More filters
Journal ArticleDOI
Sequencing-based methods and resources to study antimicrobial resistance.
TL;DR: Focusing on sequence-based discovery of antibiotic resistance genes, this Review discusses computational strategies and resources for resistance gene identification in genomic and metagenomic samples, including recent deep-learning approaches.
Journal ArticleDOI
The rapid spread of carbapenem-resistant Enterobacteriaceae
TL;DR: The novel β-lactamase inhibitor, avibactam, combined with ceftazidime or aztreonam, is a promising CRE treatment compared to current colistin or tigecycline regimens and improves characterization of co-occurrence of other antibiotic resistance genes in CRE isolates and helps identify pan-drug resistance mechanisms.
Journal ArticleDOI
Infant diet and maternal gestational weight gain predict early metabolic maturation of gut microbiomes
Aimee M. Baumann-Dudenhoeffer,Alaric W. D’Souza,Phillip I. Tarr,Barbara B. Warner,Gautam Dantas +4 more
TL;DR: Clinically important microbial pathways with statistically significant dietary correlates included dysbiotic markers6,7, core enterotype features8, and synthesis pathways for enteroprotective and immunomodulatory10,11 metabolites, epigenetic mediators1, and developmentally critical vitamins12, warranting further investigation.
Journal ArticleDOI
Environmental remodeling of human gut microbiota and antibiotic resistome in livestock farms
Jian Sun,Xiao-Ping Liao,Alaric W. D’Souza,Manish Boolchandani,Shenghui Li,Shenghui Li,Ke Cheng,José L. Martínez,Liang Li,You Jun Feng,Liang Xing Fang,Ting Huang,Jing Xia,Yang Yu,Yu-Feng Zhou,Yong Xue Sun,Xian Bo Deng,Z. L. Zeng,Hong-Xia Jiang,Bing Hu Fang,You-Zhi Tang,Xin Lei Lian,Rong Min Zhang,Zhiwei Fang,Qiu Long Yan,Gautam Dantas,Ya Hong Liu +26 more
TL;DR: It is shown that farm exposure shapes the gut microbiome of students, resulting in enrichment of potentially pathogenic taxa and antimicrobial resistance genes, and acute changes in a human’s living environment can persistently shape their gut microbiota and antibiotic resistome.
Journal ArticleDOI
Malignant Cancer and Invasive Placentation: a case for positive pleiotropy between endometrial and malignancy phenotypes
TL;DR: It is argued that the secondary evolution of less invasive placentation in some mammalian lineages may have resulted in positive pleiotropic effects on cancer survival by lowering malignancy rates and would manifest themselves as resistance to cancer cell invasion.