A
Alasdair M. Barr
Researcher at University of British Columbia
Publications - 231
Citations - 7960
Alasdair M. Barr is an academic researcher from University of British Columbia. The author has contributed to research in topics: Antipsychotic & Clozapine. The author has an hindex of 45, co-authored 211 publications receiving 6915 citations. Previous affiliations of Alasdair M. Barr include UBC Hospital & Scripps Research Institute.
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Peripheral adrenoceptors: the impetus behind glucose dysregulation and insulin resistance.
TL;DR: The present review addresses both functional and pathophysiological roles of the mammalian α1, α2, and β‐adrenoceptor isoforms in whole‐body glucose turnover and highlights evidence relating to the clinical use of common adrenergic drugs and their impacts on glucose metabolism.
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Pharmacological Risk Factors for Delirium after Cardiac Surgery: A Review
Lurdes Tse,Stephan K. W. Schwarz,John B. Bowering,Randell L. Moore,Kyle D. Burns,Carole M. Richford,Jill A. Osborn,Alasdair M. Barr +7 more
TL;DR: These studies have shown that drugs taken perioperatively by cardiac surgery patients need to be considered in delirium risk management strategies, and specific cardiovascular drugs may also require attention.
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Loss of Munc18-1 long splice variant in GABAergic terminals is associated with cognitive decline and increased risk of dementia in a community sample.
Alfredo Ramos-Miguel,Alfredo Ramos-Miguel,Christa Hercher,Christa Hercher,Clare L. Beasley,Clare L. Beasley,Alasdair M. Barr,Alasdair M. Barr,Thomas A. Bayer,Peter Falkai,Sue Leurgans,Julie A. Schneider,David A. Bennett,William G. Honer,William G. Honer +14 more
TL;DR: M18L was localized to presynaptic inhibitory terminals, and was associated with cognitive function and protection from dementia in an elderly, community-based cohort, and may be an early, independent contributor to cognitive decline.
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Effects of chronic mild stress on motivation for sucrose: mixed messages
TL;DR: The ability to replicate the basic aspects of the CMS model, and an issue related to construct validity, namely whether certain aspects of incentive motivation are affected by CMS are addressed.
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Selective effects of typical antipsychotic drugs on SNAP-25 and synaptophysin in the hippocampal trisynaptic pathway
TL;DR: Results indicate that presynaptic proteins represent a potential molecular substrate for the effects of antipsychotic drugs on hippocampal synaptic connectivity.