A
Alasdair M. Barr
Researcher at University of British Columbia
Publications - 231
Citations - 7960
Alasdair M. Barr is an academic researcher from University of British Columbia. The author has contributed to research in topics: Antipsychotic & Clozapine. The author has an hindex of 45, co-authored 211 publications receiving 6915 citations. Previous affiliations of Alasdair M. Barr include UBC Hospital & Scripps Research Institute.
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Journal ArticleDOI
Effects of sub-chronic clozapine and haloperidol administration on brain lipid levels.
Vilte E. Barakauskas,Athena R. Ypsilanti,Alasdair M. Barr,Sheila M. Innis,William G. Honer,Clare L. Beasley +5 more
TL;DR: The results indicate that brain lipid composition and plasma cholesterol concentrations are not altered following administration of antipsychotics, and suggest that observed alterations in brain lipid profiles in individuals with schizophrenia are not a consequence of treatment with antipsychotic medications.
Journal ArticleDOI
Clozapine administered once versus twice daily: does it make a difference?
TL;DR: It is hypothesized that optimal treatment with clozapine requires it to be given twice daily rather than once daily, and some pharmacokinetic simulations and published data are presented to support this hypothesis.
Journal ArticleDOI
The synaptic pathology of cognitive life
William G. Honer,A. Ramos-Miguel,Jehan Alamri,Ken Sawada,Alasdair M. Barr,Julie A. Schneider,David A. Bennett +6 more
TL;DR: Non-denaturing gels identified multiple soluble N-ethylmaleimide-sensitive factor attachment protein receptor protein-protein (SNARE) complexes in frontal and in temporal lobes, making specific contributions to cognitive functions.
Journal ArticleDOI
Prefrontal fatty acid composition in schizophrenia and bipolar disorder: Association with reelin expression
Clare L. Beasley,William G. Honer,Alfredo Ramos-Miguel,Fidel Vila-Rodriguez,Alasdair M. Barr +4 more
TL;DR: Phospholipids and fatty acids in the dorsolateral cortex do not differ in patients with schizophrenia, bipolar disorder and controls, suggesting further study of potential physiological interactions between these substrates is warranted.
Journal ArticleDOI
A comparison of regional brain volumes and white matter connectivity in subjects with stimulant induced psychosis versus schizophrenia.
Peter D Alexander,Kristina M. Gicas,Alex Cheng,Donna J. Lang,Ric M. Procyshyn,Alexandra T. Vertinsky,William J. Panenka,Allen E. Thornton,Alexander Rauscher,Jamie Y X Wong,Tasha Chan,Andrea A. Jones,Fidel Vila-Rodriguez,William G. Honer,Alasdair M. Barr +14 more
TL;DR: These findings reveal both similarities and differences between SIP and schizophrenia, and suggest schizophrenia with concurrent stimulant dependence may be associated with a different clinical and neuroanatomical profile as compared to schizophrenia alone.