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Alasdair M. Barr
Researcher at University of British Columbia
Publications - 231
Citations - 7960
Alasdair M. Barr is an academic researcher from University of British Columbia. The author has contributed to research in topics: Antipsychotic & Clozapine. The author has an hindex of 45, co-authored 211 publications receiving 6915 citations. Previous affiliations of Alasdair M. Barr include UBC Hospital & Scripps Research Institute.
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Prenatal ethanol exposure in rats decreases levels of complexin proteins in the frontal cortex.
TL;DR: Prenatal exposure to ethanol is associated with a selective loss of complexin proteins in the frontal cortex, and the combined findings suggest that further study ofcomplexin proteins as a substrate for cognitive impairment related to prenatal exposure toanol is warranted.
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Therapeutic Drug Levels of Second Generation Antipsychotics in Youth: A Systematic Review
Zachary Whitney,Heidi N. Boyda,Ric M. Procyshyn,Dean Elbe,Tyler Black,Ali Eslami,Alasdair M. Barr +6 more
TL;DR: The only SGA that may require routine therapeutic drug monitoring (TDM) in youth given the current body of research is clozapine; highly variable results were seen in studies of aripiprazole, olanzapine, and risperidone, indicating that more research is needed on plasma levels with these drugs.
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Neurocognitive profiles of marginally housed persons with comorbid substance dependence, viral infection, and psychiatric illness.
Kristina M. Gicas,Fidel Vila-Rodriguez,Karine Paquet,Alasdair M. Barr,Ric M. Procyshyn,Donna J. Lang,Geoffrey N. Smith,Heather A. Baitz,Chantelle J. Giesbrecht,Julio S. G. Montaner,Mel Krajden,Michael Krausz,G. William MacEwan,William J. Panenka,William G. Honer,Allen E. Thornton +15 more
TL;DR: Neurocognitive functioning provides the basis for identifying meaningful subgroups of marginally housed individuals, which can be reliably differentiated on key variables, and facilitates an understanding of the neurocognitive dysfunction and associated vulnerabilities of marginalized persons.
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The reelin receptors VLDLR and ApoER2 regulate sensorimotor gating in mice.
TL;DR: Reelin receptor function appears to be critically involved in crossmodal PPI and the modulation of the PPI response by NMDA receptors, which has relevance to a range of neuropsychiatric disorders that involve sensorimotor gating deficits, including schizophrenia.
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Association between Serum Lipids and Antipsychotic Response in Schizophrenia
TL;DR: Evidence suggests that increases in serum lipids may be associated with decreases in symptoms during antipsychotic treatment and this inverse association may be independent of confounding variables, such as weight gain, and may be most evident during treatment with clozapine.