Alasdair M. Barr

TL;DR: It is indicated that iloperidone exerts behavioral effects in pharmacological models of disrupted sensorimotor gating consistent with "atypical" antipsychotics, mediated by antagonism of dopaminergic and noradrenergic receptors.

TL;DR: Data demonstrate that ECS treatment results in a down‐regulation of cortical and an up-regulation of subcortical endocannabinoid activity, illustrating the possibility that the role of the endoc cannabinoidoid system in affective illness may be both complex and regionally specific.

TL;DR: There is a lack of clinical studies investigating autonomic dysfunction and a limited use of interventions to manage cardiovascular side effects associated with clozapine, which highlights the need for better designed studies, use of autonomic tests for prevention of cardiovascular disease and development of novel interventions for clozAPine-induced side effects.

TL;DR: In the group of animals challenged only once per week with olanzapine, the metabolic side-effects markedly intensified with the passage of time, whereby glucose intolerance and insulin resistance increased significantly compared to both baseline values and all other treatment groups.

TL;DR: The findings support the hypothesis of upregulated SNARE complex formation in schizophrenia OFC, possibly favored by enhanced affinity for Munc18-1 and/or Cplx1, and offer new therapeutic targets for schizophrenia.