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Aldo Amaya
Researcher at Broad Institute
Publications - 4
Citations - 277
Aldo Amaya is an academic researcher from Broad Institute. The author has contributed to research in topics: Allele & Iron-deficiency anemia. The author has an hindex of 3, co-authored 4 publications receiving 217 citations. Previous affiliations of Aldo Amaya include California State University.
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Journal ArticleDOI
Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects
Yang Zhou,Yang Zhou,Tobias Kaiser,Patricia Monteiro,Patricia Monteiro,Patricia Monteiro,Xiangyu Zhang,Marie Sophie van der Goes,Dongqing Wang,Boaz Barak,Menglong Zeng,Menglong Zeng,Chenchen Li,Chenchen Li,Congyi Lu,Congyi Lu,Michael F. Wells,Michael F. Wells,Aldo Amaya,Shannon Nguyen,Michael C. Lewis,Neville E. Sanjana,Neville E. Sanjana,Yongdi Zhou,Mingjie Zhang,Feng Zhang,Zhanyan Fu,Zhanyan Fu,Guoping Feng,Guoping Feng,Guoping Feng +30 more
TL;DR: In this paper, the authors characterized two lines of mutant mice with Shank3 mutations linked to ASD and schizophrenia and found both shared and distinct synaptic and behavioral phenotypes, which may inform exploration of these relationships in human patients.
Journal ArticleDOI
Functionally Biased D2R Antagonists: Targeting the β-Arrestin Pathway to Improve Antipsychotic Treatment
Michel Weïwer,Qihong Xu,Jennifer P. Gale,Michael C. Lewis,Arthur J. Campbell,Frederick A. Schroeder,Genevieve C. Van de Bittner,Michelle Walk,Aldo Amaya,Ping Su,Luka D̵ordevic,Joshua R. Sacher,Adam Skepner,David Fei,Kelly Dennehy,Shannon Nguyen,Patrick W. Faloon,José Carlos Rodríguez Pérez,Jeffrey R. Cottrell,Fang Liu,Michelle Palmer,Jen Q. Pan,Jacob M. Hooker,Yan-Ling Zhang,Edward M. Scolnick,Florence F. Wagner,Edward B. Holson +26 more
TL;DR: BRD5814 is characterized, a highly brain penetrant β-arrestin biased D2R antagonist that demonstrated good target engagement via PET imaging, achieving efficacy in an amphetamine-induced hyperlocomotion mouse model with strongly reduced motoric side effects in a rotarod performance test.
Journal ArticleDOI
Helicobacter pylori infection and low dietary iron alter behavior, induce iron deficiency anemia, and modulate hippocampal gene expression in female C57BL/6 mice
Monika Burns,Aldo Amaya,Caroline Bodi,Zhongming Ge,Vasudevan Bakthavatchalu,Kathleen Ennis,Timothy C. Wang,Michael K. Georgieff,James G. Fox +8 more
TL;DR: The mouse model developed in this study is a useful model to study the neurologic, behavioral, and hematologic impact of the common human co-morbidity of H. pylori infection and IDA.
Journal ArticleDOI
The effect of scopolamine on matching behavior and the estimation of relative reward magnitude.
TL;DR: The results suggest a cholinergic basis for the computation of choice variables related to matching behavior and scopolamine hydrobromide led to a reduction in the relative magnitude of reward.