Aldo Orlacchio

TL;DR: Hematopoietic stem cell–specific microRNAs allow regulation of therapeutic transgene expression and enable effective gene therapy of globoid cell leukodystrophy and provide a basis for improvements in HSPC-mediated gene therapy and may offer patients a new therapeutic option that resembles a scratch more than a chop.

TL;DR: In this review, the challenges behind translating stem cell biology and biomaterial innovations into novel clinical therapeutic applications for tissue and organ replacements are reported on.

TL;DR: The most recent insights into the involvement of miRNAs in the biology of the nervous system and the occurrence of neuropathological disorders are reviewed and discussed.

TL;DR: It is demonstrated that miR-128 inhibition in monocytes from AD patients improves Aβ(1-42) degradation and could contribute to clarify the molecular mechanisms that affect the imbalanced Aβ production/clearance involved in the pathogenesis of AD.

TL;DR: It is indicated that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysOSomal hydrosidases.