T
Toshitaka Kawarai
Researcher at University of Tokushima
Publications - 132
Citations - 7307
Toshitaka Kawarai is an academic researcher from University of Tokushima. The author has contributed to research in topics: Hereditary spastic paraplegia & Presenilin. The author has an hindex of 40, co-authored 131 publications receiving 6778 citations. Previous affiliations of Toshitaka Kawarai include University Health Network & University of Toronto.
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Journal ArticleDOI
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
Ekaterina Rogaeva,Ekaterina Rogaeva,Yan Meng,Joseph H. Lee,Yongjun Gu,Yongjun Gu,Toshitaka Kawarai,Toshitaka Kawarai,Fanggeng Zou,Taiichi Katayama,Taiichi Katayama,Clinton T. Baldwin,Rong Cheng,Hiroshi Hasegawa,Hiroshi Hasegawa,Fusheng Chen,Fusheng Chen,Nobuto Shibata,Nobuto Shibata,Kathryn L. Lunetta,Raphaëlle Pardossi-Piquard,Raphaëlle Pardossi-Piquard,Christopher Bohm,Christopher Bohm,Yosuke Wakutani,Yosuke Wakutani,L. Adrienne Cupples,Karen T. Cuenco,Robert C. Green,Lorenzo Pinessi,Innocenzo Rainero,Sandro Sorbi,Amalia C. Bruni,Ranjan Duara,Ranjan Duara,Robert P. Friedland,Rivka Inzelberg,Wolfgang Hampe,Hideaki Bujo,You-Qiang Song,Olav M. Andersen,Thomas E. Willnow,Neill R. Graff-Radford,Ronald C. Petersen,Dennis W. Dickson,Sandy D. Der,Sandy D. Der,Paul E. Fraser,Paul E. Fraser,Gerold Schmitt-Ulms,Gerold Schmitt-Ulms,Steven G. Younkin,Richard Mayeux,Lindsay A. Farrer,Lindsay A. Farrer,Peter St George-Hyslop,Peter St George-Hyslop +56 more
TL;DR: It is reported here that inherited variants in the SORL1 neuronal sorting receptor are associated with late-onset Alzheimer disease, and it is shown that SOR l1 directs trafficking of APP into recycling pathways and that when SORl1 is underexpressed, APP is sorted into Aβ-generating compartments.
Journal ArticleDOI
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing
Gang Yu,Masaki Nishimura,Shigeki Arawaka,Shigeki Arawaka,Diane Levitan,Lili Zhang,Anurag Tandon,Anurag Tandon,You-Qiang Song,You-Qiang Song,Ekaterina Rogaeva,Ekaterina Rogaeva,Fusheng Chen,Fusheng Chen,Toshitaka Kawarai,Toshitaka Kawarai,Agnes Supala,Agnes Supala,Lyne Levesque,Lyne Levesque,Haung Yu,Haung Yu,Dun-Sheng Yang,Dun-Sheng Yang,Erin Holmes,Erin Holmes,Paul Milman,Paul Milman,Yan Liang,Yan Liang,Dong Mel Zhang,Dong Mel Zhang,Dong Hong Xu,Dong Hong Xu,Christine Sato,Christine Sato,Evgeny I. Rogaev,Evgeny I. Rogaev,Marsha Smith,Christopher Janus,Christopher Janus,Yanni Zhang,Ruedl Aebersold,Lindsay A. Farrer,Sandro Sorbl,Amalia C. Bruni,Paul E. Fraser,Paul E. Fraser,Peter St George-Hyslop,Peter St George-Hyslop +49 more
TL;DR: Nicastrin and presenilins are likely to be functional components of a multimeric complex necessary for the intramembranous proteolysis of proteins such as Notch/GLP-1 and βAPP.
Journal ArticleDOI
Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations.
Agnes Petit,Toshitaka Kawarai,Erwan Paitel,Nobuo Sanjo,Mary C. Maj,Michael P. Scheid,Fusheng Chen,Yongjun Gu,Hiroshi Hasegawa,Shabnam Salehi-Rad,Linda Wang,Ekaterina Rogaeva,Paul E. Fraser,Brian D. Robinson,Peter St George-Hyslop,Anurag Tandon +15 more
TL;DR: Results suggest that PINK1 reduces the basal neuronal pro-apoptotic activity and protects neurons from staurosporine-induced apoptosis, and loss of this protective function may underlie the degeneration of nigral dopaminergic neurons in patients with Pink1 mutations.
Journal ArticleDOI
TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.
Fusheng Chen,Hiroshi Hasegawa,Hiroshi Hasegawa,Gerold Schmitt-Ulms,Toshitaka Kawarai,Christopher Bohm,Taiichi Katayama,Yongjun Gu,Nobuo Sanjo,Nobuo Sanjo,Michael Glista,Ekaterina Rogaeva,Yosuke Wakutani,Raphaëlle Pardossi-Piquard,Xueying Ruan,Anurag Tandon,Frédéric Checler,Philippe Marambaud,Kirk C. Hansen,David Westaway,Peter St George-Hyslop,Peter St George-Hyslop,Paul E. Fraser +22 more
TL;DR: It is reported that TMP21, a member of the p24 cargo protein family, is a component of presenilin complexes and differentially regulates γ- secretase cleavage without affecting ɛ-secretase activity.
Journal ArticleDOI
Hereditary spastic paraplegia: Clinical-genetic characteristics and evolving molecular mechanisms
Temistocle Lo Giudice,Federica Lombardi,Filippo M. Santorelli,Toshitaka Kawarai,Antonio Orlacchio +4 more
TL;DR: Interactome networks have been postulated by bioinformatics and biological analyses of spastic paraplegia genes, which would contribute to the development of new therapeutic approaches.