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Alec Uebersohn
Researcher at University of California, Berkeley
Publications - 5
Citations - 1499
Alec Uebersohn is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: CTCF & Insulator (genetics). The author has an hindex of 4, co-authored 5 publications receiving 1080 citations. Previous affiliations of Alec Uebersohn include Gladstone Institutes.
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Journal ArticleDOI
Targeted Degradation of CTCF Decouples Local Insulation of Chromosome Domains from Genomic Compartmentalization.
Elphège P. Nora,Anton Goloborodko,Anne-Laure Valton,Johan H. Gibcus,Alec Uebersohn,Nezar Abdennur,Job Dekker,Leonid A. Mirny,Benoit G. Bruneau +8 more
TL;DR: The data support that CTCF mediates transcriptional insulator function through enhancer blocking but not as a direct barrier to heterochromatin spreading, and provides new fundamental insights into the rules governing mammalian genome organization.
Journal ArticleDOI
KMT2D regulates specific programs in heart development via histone H3 lysine 4 di-methylation
TL;DR: It is demonstrated that KMT2D is essential for regulating cardiac gene expression during heart development primarily via H3K4 di-methylation, which causes dysregulation of genes associated with cell cycle regulation, ion homeostasis and hypoxia signaling.
Journal ArticleDOI
Molecular basis of CTCF binding polarity in genome folding
Elphège P. Nora,Laura Caccianini,Geoffrey Fudenberg,Kevin So,Vasumathi Kameswaran,Abigail Nagle,Abigail Nagle,Alec Uebersohn,Alec Uebersohn,Bassam Hajj,Agnes Le Saux,Agnes Le Saux,Antoine Coulon,Leonid A. Mirny,Katherine S. Pollard,Katherine S. Pollard,Maxime Dahan,Benoit G. Bruneau +17 more
TL;DR: It is reported that CTCF positions cohesin, but does not control its overall binding dynamics on chromatin, by combining ChIP-seq and single molecule live imaging and using an inducible complementation system.
Posted ContentDOI
Targeted degradation of CTCF decouples local insulation of chromosome domains from higher-order genomic compartmentalization
Elphège P. Nora,Anton Goloborodko,Anne-Laure Valton,Johan H. Gibcus,Alec Uebersohn,Nezar Abdennur,Job Dekker,Leonid A. Mirny,Benoit G. Bruneau +8 more
TL;DR: The data supports that CTCF mediates transcriptional insulator function through enhancer-blocking but not direct chromatin barrier activity, and provides new fundamental insights into the rules governing mammalian genome organization.
Posted ContentDOI
Targeted degradation of CTCF decouples local insulation of chromosome domains from higher-order genomic compartmentalization [preprint]
Elphège P. Nora,Anton Goloborodko,Anne-Laure Valton,Johan H. Gibcus,Alec Uebersohn,Nezar Abdennur,Job Dekker,Leonid A. Mirny,Benoit G. Bruneau +8 more